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83880-65-3

21-CHLORO-9,11-EPOXY-17-HYDROXY-16-METHYL-1,4-, also known as Mometasone Furoate Impurity A, is a chemical compound derived from Mometasone Furoate. It is characterized by its unique chemical structure, which includes a chloro, epoxy, hydroxy, and methyl groups. As a white solid, it possesses specific chemical properties that make it useful in various applications.

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  • 83880-65-3 Structure

  • Basic information

    1. Product Name: 21-CHLORO-9,11-EPOXY-17-HYDROXY-16-METHYL-1,4-
    2. Synonyms: 21-CHLORO-9,11-EPOXY-17-HYDROXY-16-METHYL-1,4-;MoMetasone Furoate IMpurity A;Mometasone Furoate EP Impurity A;Mometasone Impurity A
    3. CAS NO:83880-65-3
    4. Molecular Formula: C27H29ClO5
    5. Molecular Weight: 468.96916
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 83880-65-3.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: -20°C Freezer
    8. Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Very Slightly, Sonicated)
    9. CAS DataBase Reference: 21-CHLORO-9,11-EPOXY-17-HYDROXY-16-METHYL-1,4-(CAS DataBase Reference)
    10. NIST Chemistry Reference: 21-CHLORO-9,11-EPOXY-17-HYDROXY-16-METHYL-1,4-(83880-65-3)
    11. EPA Substance Registry System: 21-CHLORO-9,11-EPOXY-17-HYDROXY-16-METHYL-1,4-(83880-65-3)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 83880-65-3(Hazardous Substances Data)

83880-65-3 Usage

Uses

Used in Pharmaceutical Industry:
21-CHLORO-9,11-EPOXY-17-HYDROXY-16-METHYL-1,4is used as an impurity in the production of Mometasone Furoate, a topical corticosteroid. It serves as a critical component in the synthesis process, contributing to the development of anti-inflammatory medications.
As an Anti-Inflammatory Agent:
Although primarily an impurity, 21-CHLORO-9,11-EPOXY-17-HYDROXY-16-METHYL-1,4may also possess anti-inflammatory properties due to its structural similarities with Mometasone Furoate. This could potentially allow it to be used or studied for its own anti-inflammatory effects in various applications.
In Research and Development:
21-CHLORO-9,11-EPOXY-17-HYDROXY-16-METHYL-1,4can be utilized in research settings to understand its properties, effects, and potential applications further. This may include studying its interactions with biological systems, its role in the synthesis of Mometasone Furoate, and its potential as a standalone therapeutic agent.

Check Digit Verification of cas no

The CAS Registry Mumber 83880-65-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,3,8,8 and 0 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 83880-65:
(7*8)+(6*3)+(5*8)+(4*8)+(3*0)+(2*6)+(1*5)=163
163 % 10 = 3
So 83880-65-3 is a valid CAS Registry Number.

83880-65-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 21-chloro-16α-methyl-17α-hydroxy-1,4,9(11)-pregnatriene-3,20-dione 17-(2'-furoate)

1.2 Other means of identification

Product number -
Other names Mometasone Furoate Impurity A

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:83880-65-3 SDS

83880-65-3Relevant articles and documents

Preparation method of mometasone furoate

-

, (2021/10/20)

The invention relates to the technical field of chemical pharmacy, in particular to a preparation method of mometasone furoate. The preparation method comprises the following steps: carrying out a cyanohydrination reaction on a compound I to obtain a compound II, carrying out an alkylation reaction on the compound II to obtain a compound III, carrying out an intramolecular substitution reaction on the compound III to obtain a compound IV, carrying out a furfurylation reaction on the compound IV to obtain a compound V, and finally carrying out a chlorohydroxyl reaction on the compound V to obtain mometasone furoate. The mometasone furoate is obtained by adopting the compound I through the cyanohydrination reaction, the alkylation reaction, the intramolecular substitution reaction, the furfurylation reaction and the chlorohydroxyl reaction, the quality and the yield of the obtained mometasone furoate have obvious competitiveness, the quality yield is high, the purity is high, the purity reaches 99.20% or above, and the content of any impurity is smaller than 0.10%. The preparation method of mometasone furoate provided by the invention adopts the easily prepared compound I as the raw material, and is low in cost, green and environment-friendly.

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