83882-87-5Relevant academic research and scientific papers
Visible Light Copper Photoredox-Catalyzed Aerobic Oxidative Coupling of Phenols and Terminal Alkynes: Regioselective Synthesis of Functionalized Ketones via C C Triple Bond Cleavage
Sagadevan, Arunachalam,Charpe, Vaibhav Pramod,Ragupathi, Ayyakkannu,Hwang, Kuo Chu
supporting information, p. 2896 - 2899 (2017/03/11)
Direct oxidative coupling of phenols and terminal alkynes was achieved at room temperature by a visible-light-mediated copper-catalyzed photoredox process. This method allows regioselective synthesis of hydroxyl-functionalized aryl and alkyl ketones from simple phenols and phenylacetylene via C C triple bond cleavage. 47 examples were presented. From a synthetic perspective, this protocol offers an efficient synthetic route for the preparation of pharmaceutical drugs, such as pitofenone and fenofibrate.
Synthesis and structure-affinity relationships of 1-[ω-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT7 receptor ligands
Perrone, Roberto,Berardi, Francesco,Colabufo, Nicola A.,Lacivita, Enza,Leopoldo, Marcello,Tortorella, Vincenzo
, p. 646 - 649 (2007/10/03)
Structural requirements for 5-HT7 receptor affinity and selectivity over that for the 5-HT1A receptor were studied on a series of 1-[ω-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones. The presence of a hydroxy or methoxy substituent on aryl ketone moiety, alkyl chain length, and the nature of N-1-piperazine substituent were explored. 6-[4-(3-Benzisoxazolyl)-1-piperazinyl]-1-(2-hydroxyphenyl)-1-hexanone (40) and its methoxy analogue 43 exhibited high 5-HT7 receptor affinities (Ki = 2.93 nM and 0.90 nM, respectively) and agonist properties when tested for 5-HT7 receptor-mediated relaxation of substance P-induced guinea-pig ileum contraction.
A GENERAL ROUTE TO 3-(HYDROXYARYL)TETRAHYDRO PYRIDAZINES AND 1,2-DIAZEPINES AND DERIVATIVES
Kalyanam, N.,Dave, K.G.,Likhate, M.A.
, p. 2183 - 2192 (2007/10/02)
A three step synthesis of 1-acyl-3-(hydroxyaryl)tetrahydro pyridazines and 1,2-diazepines starting from phenols is described.The hydrolytic lability of some intermediate chloroalkyl aryl ketones and a simple recovery of these ketones from nitrobenzene solution are indicated.
