838823-86-2Relevant academic research and scientific papers
Structure-based design of (5-arylamino-2H-pyrazol-3-yl)-biphenyl-2′, 4′-diols as novel and potent human CHK1 inhibitors
Teng, Min,Zhu, Jinjiang,Johnson, Michael D.,Chen, Ping,Kornmann, Jill,Chen, Enhong,Blasina, Alessandra,Register, James,Anderes, Kenna,Rogers, Caroline,Deng, Yali,Ninkovic, Sacha,Grant, Stephan,Hu, Qiyue,Lundgren, Karen,Peng, Zhengwei,Kania, Robert S.
, p. 5253 - 5256 (2007)
The cocrystal structure of a library hit was used to design a novel series of CHK1 inhibitors. The new series retained the critical hydrogen-bonding groups of the resorcinol moiety for binding but lacked the phenolic anilide moiety. The newly designed com
AMINOPYRAZOLE COMPOUNDS AND USE AS CHK1 INHIBITORS
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Page/Page column 67-68, (2010/02/10)
Described herein are aminopyrazole compounds of formula (I), wherein R1, R2, L and Ar are as defined in the specification. Such compounds are capable of modulating the activity of a checkpoint kinase and methods for utilizing such mo
