83901-06-8

Upstream product

• 24647-47-0 2,2,2-Trichloroethyl (6R,7R)-3-methyl-<(phenoxyacetyl)amino>-8-oxo-5-thia-1-azabicyclo<4.2.0>oct-2-ene-2-carboxylate 
• 51-80-9 bis-(dimethylamino)methane 
• 83901-02-4 2,2,2-trichloroethyl 7β-phenylacetamido-3-methyl-3-cephem-4-carboxylate 1,1-dioxide 
• 50-00-0 formaldehyd 

Downstream Products

• 133869-65-5 C₂₃H₂₃Cl₃N₂O₈S 
• 133869-66-6 C₂₀H₁₉Cl₃N₂O₆S 

Relevant academic research and scientific papers

Mannich reactions of cephalosporin sulphoxides and sulphones with imonium salts. An improved synthesis of 2-methylene-cephalosporins

2-Methylenecephem-1-oxides (4) or -1,1-dioxides (6) can be very conveniently obtained through the use of dimethyl(methylene)imonium salts, which can be prepared in situ or in advance from bis(N,N-dimethylamino)methane (2) and a reactive acid derivative.

SYNTHESIS AND 1,3-DIPOLAR CYCLOADDITIONS OF 2-METHYLENECEPHALOSPORINS

Cephalosporin R- and S-sulphoxides were prepared.The S-sulphoxides gave Mannich-reaction resulting in the formation of 2-methylenecephalosporins.These electrom-deficient dienes underwent 1,3-dipolar cycloadditions with diazoalkanes in a chemo- and regiosp