83910-44-5Relevant articles and documents
Synthesis of β- and γ-carbolines by the palladium-catalyzed iminoannulation of alkynes
Zhang, Haiming,Larock, Richard C.
, p. 9318 - 9330 (2007/10/03)
A variety of substituted β- and γ-carbolines have been prepared in moderate to excellent yields by the palladium-catalyzed annulation of internal and terminal acetylenes by the tert-butylimines of N-substituted 3-iodoindole-2-carboxaldehydes and 2-haloindole-3-carboxaldehydes, respectively. This annulation chemistry is effective for a wide range of alkynes, including aryl-, alkyl-, hydroxymethyl-, ethoxycarbonyl-, and trimethylsilyl-substituted alkynes. When an unsymmetrical internal alkyne is employed, this method generally gives two regioisomers. When a terminal alkyne is employed, only one regioisomer has been isolated. This palladium-catalyzed annulation chemistry has also been successfully applied to the synthesis of two biologically interesting β-carboline alkaloids, ZK93423 and abecarnil (ZK112119).
Benzodiazepine-receptor (BZR) Ligands: the Conformational Fit of Agonist &β-Carbolines to an Imidazobenzodiazepine Template
Fryer, R. Ian,Wang, C.-G.,Chia, N.-C.,Basile, A. S.,Gu, Z.-Q.,Skolnick, P.
, p. 296 - 307 (2007/10/03)
This work describes the rationale for the design and synthesis as well as the in vitro biological evaluation of three novel analogs of ethyl 6-benzyloxy-4-methoxymethyl-β-carboline-3-carboxylate (ZK93423), a BZR agonist ligand. Previous computer graphics