83948-32-7

Upstream product

• 61203-53-0 2-iodo-4,5-dimethoxybenzaldehyde 
• 1730-25-2 allylmagnesium bromide 
• 83948-26-9 [1-(2-Iodo-4,5-dimethoxy-phenyl)-meth-(E)-ylidene]-trimethylsilanyl-amine 

Downstream Products

• 80696-85-1 N-<1-(3,4-dimethoxy-6-iodophenyl)but-3-en-1-yl>-5,5-dimethoxypentanamide 
• 80696-89-5 rel-(2S,4S,10R)-4-(3,4-dimethoxy-6-iodophenyl)-2-(formyloxy)octahydro-4H-quinolizin-6-one 
• 80696-87-3 rel-(2R,4S,10R)-4-(3,4-dimethoxy-6-iodophenyl)-2-(formyloxy)octahydro-4H-quinolizin-6-one 
• 80696-99-7 rel-(2R,4S,10R)-2-acetoxy-4-(3,4-dimethoxy-6-iodophenyl)octahydro-4H-quinolizine 
• 60352-71-8 Acetic acid (2R,4R,9aS)-4-(3,4-dimethoxy-phenyl)-octahydro-quinolizin-2-yl ester 
• 80696-93-1 rel-(4S,10R)-4-(3,4-dimethoxy-6-iodophenyl)-1,6,7,8,9,10-hexahydro-4H-quinolizin-6-one 
• 80696-92-0 rel-(4S,10R)-4-(3,4-dimethoxy-6-iodophenyl)-1,6,7,8,9,10-hexahydro-4H-quinolizin-6-one 
• 53510-38-6 methyl 3-<4-<2--4,5-dimethoxyphenoxy>phenyl>propionate 
• 53425-29-9 3-{4-[2-((2S,9aR)-2-Hydroxy-octahydro-quinolizin-4-yl)-4,5-dimethoxy-phenoxy]-phenyl}-propionic acid 

Relevant academic research and scientific papers

Preparation of Primary Amines and 2-Azetidinones via N-Trimethylsilyl Imines

Nonenolizable aldehydes react with lithium bis(trimethylsilyl)amide at ambient temperatures to afford solutions of N-trimethylsilyl aldimines.Treatment of these solutions with Grignard reagents or alkyllithiums followed by an aqueous workup gives primary amines in moderate to excellent yields.Treatment of N-trimethylsilyl aldimines with ester enolates provides an expedient route to 1-unsubstituted 2-azetidinones.

New Approach to Lythraceae Alkaloids: Total Synthesis of (+/-)-Vertaline

A new approach to Lythraceae alkaloids is described within the context of a total synthesis of (+/-)-vertaline (2).The use of N-silyl imines in the preparation of benzylic amines as well as a stereoselective bicycloannelation approach to the synthesis of quinolizidinones is discussed.