83948-32-7Relevant articles and documents
Preparation of Primary Amines and 2-Azetidinones via N-Trimethylsilyl Imines
Hart, David J.,Kanai, Ken-ichi,Thomas, Dudley G.,Yang, Teng-Kuei
, p. 289 - 294 (2007/10/02)
Nonenolizable aldehydes react with lithium bis(trimethylsilyl)amide at ambient temperatures to afford solutions of N-trimethylsilyl aldimines.Treatment of these solutions with Grignard reagents or alkyllithiums followed by an aqueous workup gives primary amines in moderate to excellent yields.Treatment of N-trimethylsilyl aldimines with ester enolates provides an expedient route to 1-unsubstituted 2-azetidinones.
New Approach to Lythraceae Alkaloids: Total Synthesis of (+/-)-Vertaline
Hart, David J.,Kanai, Ken-ichi
, p. 1555 - 1560 (2007/10/02)
A new approach to Lythraceae alkaloids is described within the context of a total synthesis of (+/-)-vertaline (2).The use of N-silyl imines in the preparation of benzylic amines as well as a stereoselective bicycloannelation approach to the synthesis of quinolizidinones is discussed.