83948-42-9Relevant academic research and scientific papers
Fibrinogen receptor antagonist and pharmaceutical compositions comprising the same
-
, (2008/06/13)
Compounds of the following general formula (I) and pharmaceutically acceptable salts thereof.
NOVEL SYNTHESIS OF THIANONANAM USING SULFUR DICHLORIDE AS A SULFUR TRANSFER REAGENT
Komatsu, Mitsuo,Mohri, Masaaki,Kume, Shoichiro,Ohshiro, Yoshiki
, p. 659 - 662 (2007/10/02)
Hitherto unknown or rarely reported sulfur-containing bicyclic β-lactams, 6- and 7-thianonanams, were synthesized by addition of sulfur dichloride to N-allyl-β-styryl-β-lactam.
Reaction of Silylimines with Ester Enolates. Synthesis of N-Unsubstituted Azetidinones Starting from Nitriles
Andreoli, Patrizia,Cainelli, Gianfranco,Contento, Michele,Giacomini, Daria,Martelli, Giorgio,Panunzio, Mauro
, p. 945 - 948 (2007/10/02)
The reduction of aromatic, vinylic, and aliphatic nitriles with several 'metal-aluminium hydrides' produces an addition product which is readly converted to a β-lactam derivative by treatment with Me3SiCl followed by the addition of lithium ester enolates.The factors influencing the course of the cycloaddition-type reaction are discussed.A relatively simple synthetic procedure for the preparation of N-unsubstituted azetidin-2-ones in satisfactory yields is reported.
A SYNTHETIC APPROACH TO AZETIDINONES FROM NITRILES AND LITHIUMTRIETHOXYALUMINIUM HYDRIDE.
Andreoli, P.,Cainelli, G.,Contento, M.,Giacomini, D.,Martelli, G.,Panunzio, M.
, p. 1695 - 1698 (2007/10/02)
A convenient one-pot process for direct conversion of nitriles to 3,4-disubstituted azetidinones has been developed.
Preparation of Primary Amines and 2-Azetidinones via N-Trimethylsilyl Imines
Hart, David J.,Kanai, Ken-ichi,Thomas, Dudley G.,Yang, Teng-Kuei
, p. 289 - 294 (2007/10/02)
Nonenolizable aldehydes react with lithium bis(trimethylsilyl)amide at ambient temperatures to afford solutions of N-trimethylsilyl aldimines.Treatment of these solutions with Grignard reagents or alkyllithiums followed by an aqueous workup gives primary amines in moderate to excellent yields.Treatment of N-trimethylsilyl aldimines with ester enolates provides an expedient route to 1-unsubstituted 2-azetidinones.
