83958-64-9Relevant academic research and scientific papers
Anti-ulcer and gastric antisecretory activity of a series of thioethers and related sulphoxides
Beattie,Crossley,Dickinson,Dover
, p. 277 - 285 (2007/10/02)
A series of thioethers containing a pyridinium moiety were prepared and tested for gastric antisecretory and anti-ulcer activity. Following initial screening two compounds 2-(3-chlorobenzylthio)-1-methylpyridinium chloride and 2-(2-fluorobenzylthio)-1-methylpyridinium chloride were investigated further. By modification of substituent groups some separation of anti-ulcer and antisecretory activity was achieved. Subsequently it was found that the pyridinium moiety could be replaced and a number of related thioethers and sulphoxides were synthesised and were also found to be active. A wide range of structural variations were found to be possible with retention of activity.
Dithiocompounds
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, (2008/06/13)
Novel compounds of formula I STR1 are described wherein R is lower alkyl, phenyl or aralkyl of 7 to 12 carbon atoms, R1 is hydrogen, lower alkyl, hydroxyloweralkyl, loweralkoxyloweralkyl, lower alkoxy, halogen, formyl, phenyl, phenylalkyl or ac
