83961-08-4Relevant academic research and scientific papers
Preparation method of 3-cyclopropyl cyclobutanone
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Paragraph 0027-0033, (2019/07/16)
The present invention discloses a preparation method of 3-cyclopropyl cyclobutanone, and belongs to the technical field of organic synthesis. The preparation method is characterized by comprising thefollowing steps of 1, dissolving cyclopropyl acetylene in an organic solvent A under the action of a metal catalyst, cooling to 0 DEG C or lower, then adding trichloroacetyl chloride, heating to roomtemperature, and obtaining an intermediate after being subject to reacting for 7-9 hours, then filtering, drying and concentrating under reduced pressure; and 2, dissolving the intermediate obtained in the step 1 in an organic solvent B under the action of a reducing catalyst and alkali, introducing hydrogen gas, heating to 50-60 DEG C under 4-15 atm, performing filtering, and concentrating underreduced pressure to remove methanol after being subjected to reacting for 15-18 hours, and distilling under reduced pressure to obtain the 3-cyclopropyl cyclobutanone. According to the preparation method, a novel and reliable technical route and synthesis strategy are provided and the preparation method has wide application prospect in the technical field of the organic chemical synthesis.
MICROBIOCIDES
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Page/Page column 27, (2008/06/13)
The invention relates to a fungicidally active compound of the general Formula (I): where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, the ring being substi
STERICALLY SCREENED HALOGENOCYCLOBUTANONES. I. TRANSFORMATION OF CYCLOPROPYL-SUBSTITUTED 2,2-DICHLOROCYCLOBUTANONES UNDER THE INFLUENCE OF POTASSIUM HYDROXIDE
Donskaya, N. A.,Bessmertnykh, A. G.,Drobysh, V. A.,Shabarov, Yu. S.
, p. 671 - 676 (2007/10/02)
The reaction of 2,2-dichloro-3-cyclopropylcyclobutanones with potassium hydroxide was studied.The direction of the reaction depends on the concentration of the potassium hydroxide; with a 2percent solution of potassium hydroxide 4,4-dichlorobutyric acids are formed with yields of up to 80percent, and with a 15percent solution of potassium hydroxide 5-hydroxydihydro-2-furanones are formed with yields of up to 80percent.Proposals are made about mechanism of formation of 5-hydroxydihydro-2-furanones.
Vinyl Cations, 38. Synthesis and Solvolysis of 3-Substituted 1-Cyclobutenyl Nonaflates
Auchter, Gerhard,Hanack, Michael
, p. 3402 - 3413 (2007/10/02)
3-Methyl- (8a) and 3-cyclopropyl-1-cyclobutenyl nonaflate (8b) as well as 2-cyclopropyl-1-cyclobutenyl nonaflate (12) and the parent 1-cyclobutenyl nonaflate (3) were synthesized from the corresponding cyclobutanones and nonafluorobutanesulfonic anhydride (10).The solvolysis rates and the product compositions of the solvolyses in trifluoroethanol and trifluoroethanol/water mixtures were determined.All 1-cyclobutenyl nonaflates solvolyze via a SN1 mechanism involving the intermediate nonclassical 1-cyclobutenyl cation, which is additionally stabilized by the substituents in the 3-position.
