83966-49-8

Basic information

• Product Name: ingenol-20-mebutate
• Synonyms: ingenol-20-mebutate
• CAS NO: 83966-49-8
• Molecular Weight: 430.541
• Mol File: 83966-49-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ingenol-20-mebutate(CAS DataBase Reference)
• NIST Chemistry Reference: ingenol-20-mebutate(83966-49-8)
• EPA Substance Registry System: ingenol-20-mebutate(83966-49-8)

Safety Data

• Hazardous Substances Data: 83966-49-8(Hazardous Substances Data)

Upstream product

• 94487-74-8 (Z)-2-methyl-2-butenoic anhydride 
• 30220-46-3 ingenol 

Downstream Products

• 30220-46-3 ingenol 

Relevant articles and documents

A CONTINUOUS FLOW PROCESS FOR THE PREPARATION OF INGENOL-3-MEBUTATE

Disclosed is a continuous process for the preparation of ingenol-3-mebutate by reaction, in solution, of ingenol or ingenol anion and angelic anhydride or an equivalent angelylating agent. The continuous flow process is preferably performed in the presence of a base such as lithium hexamethyl disilazane (LiHMDS) and/or an activating agent such as dicyclohexylcarbodiimide (DCC). Also disclosed is a process for recycling the other reaction products obtained in the continuous process for preparation of ingenol-3-mebutate for formation of ingenol, which can then be recycled to form ingenol-3-mebutate.