94487-74-8

Basic information

• Product Name: ANGELIC ANHYDRIDE
• Synonyms: ANGELIC ANHYDRIDE;CIS-2-METHYLCROTONIC ANHYDRIDE;CIS-2,3-DIMETHYLACRYLIC ANHYDRIDE;2-METHYLISOCROTONIC ANHYDRIDE;(Z)-2-METHYL-2-BUTENOIC ANHYDRIDE;Bis[(Z)-2-methyl-2-butenoic acid] anhydride;Bis[(Z)-2-methyl-2-butenoic] anhydride;(Z)-2-Methyl-2-butenoic Anhydride 2-Methylisocrotonic Anhydride
• CAS NO: 94487-74-8
• Molecular Formula: C₁₀H₁₄O₃
• Molecular Weight: 182.22
• Mol File: 94487-74-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 108 °C / 13mmHg
• Flash Point: 119.788°C
• Appearance: /
• Density: 1,02 g/cm3
• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.4720-1.4750
• Storage Temp.: 0-10°C
• CAS DataBase Reference: ANGELIC ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: ANGELIC ANHYDRIDE(94487-74-8)
• EPA Substance Registry System: ANGELIC ANHYDRIDE(94487-74-8)

Safety Data

• RIDADR: 3265
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 94487-74-8(Hazardous Substances Data)

Usage

Uses

Angelic Anhydride is a reagent in the improved synthesis of angelate esters, which are the active chemical behind the strong pain-relieving and spasmolytic action of extracts from the plant butterbur.

InChI:InChI=1/C10H14O3/c1-5-7(3)9(11)13-10(12)8(4)6-2/h5-6H,1-4H3/b7-5-,8-6-

Upstream product

• 565-63-9 Angelic acid 
• 77573-43-4 (6S,6aR,7aR,9R,9aS,12S,12aR,12bR)-12,12a-dihydroxy-2,2,7,7,9,11-hexamethyl-4,6,6a,7,7a,8,9,12,12a,12b-decahydro-6,9a-methanocyclopenta[9,10]cyclopropa[5,6]cyclodeca[1,2-d][1,3]dioxin-13-one 

Downstream Products

• 75567-37-2 ingenol mebutate 
• 1356187-27-3 ingenol-3-tigliate 
• 87980-68-5 3-O-angeloyl-5,20-O-isopropylideneingenol 
• 1356490-35-1 ingenol-5,20-acetonide-3-tiglate 
• 77448-64-7 lychnopholide 
• 136051-63-3 nortrilobolide 
• 75567-38-3 3-tigloyl-20-deoxyingenol 
• 75567-38-3 3-O-angeloyl-20-deoxyingenol 
• 83966-49-8 ingenol-20-mebutate 
• 1356187-34-2 ingenol 3,20-di-angelate 
• 3173-03-3 Columbianadin 
• 1165-60-2 (-)-O-angeloyllomatin 
• 52617-35-3 eriolangin 

Relevant articles and documents

A METHOD OF PRODUCING INGENOL-3-ANGELATE

The present invention relates to methods of producing ingenol-3-angelate (I) from ingenol (II). Formula (I) and (II). Furthermore, the invention relates to intermediates useful for the synthesis of ingenol-3-angelate (I) from ingenol (II) and to methods of producing said intermediates.