83967-12-8Relevant academic research and scientific papers
Carbocyclic analogues of 5-substituted uracil nucleosides: Synthesis and antiviral activity
Shealy,O'Dell,Shannon,Arnett
, p. 156 - 161 (2007/10/02)
Carbocyclic analogues of 3'-deoxyuridines and uridines with substituents at position 5 of the uracil moiety were prepared by direct halogenation (5-bromo and 5-iodo groups) and by displacement of the 5-bromo group by amino and substituted-amino groups. The analogue of 5-(hydroxymethyl)uridine was prepared via reaction of the isopropylidene derivative of the uridine analogue with paraformaldehyde. The carbocyclic analogues of thymidine and of 5-bromo-, 5-iodo-, and 5-(methylamino)-2'-deoxyuridine were highly active in vitro against herpes simplex virus, types 1 and 2. The corresponding analogues of 5-substituted 3'-deoxyuridines and of 5-substituted uridines were not active in this assay.
