839710-63-3Relevant academic research and scientific papers
TiCl4-promoted multicomponent reaction: A new entry to functionalized α-amino acids
Ghosh, Arun K.,Xu, Chun-Xiao,Kulkarni, Sarang S.,Wink, Donald
, p. 7 - 10 (2005)
(Chemical Equation Presented) TiCl4-promoted multicomponent reactions involving N-tosyl imino ester, cyclic enol ether, and silane reagents in a single one-pot operation provide functionalized α-amino acids with multiple stereogenic centers in
Asymmetric multicomponent reactions: convenient access to acyclic stereocenters and functionalized cyclopentenoids
Ghosh, Arun K.,Kulkarni, Sarang S.,Xu, Chun-Xiao,Shurrush, Khriesto
, p. 1020 - 1026 (2008/09/21)
Asymmetric multicomponent reactions of optically active phenyl dihydrofuran, keto ester or N-tosyl imino ester, and allylsilane provided functionalized phenyl tetrahydrofurans with multiple stereogenic centers diastereoselectively. Cleavage of the resulting substituted tetrahydrofurans readily provided acyclic derivatives with three contiguous asymmetric centers via an acyloxycarbenium ion intermediate. Ring closing olefin metathesis, using Grubbs catalyst, afforded functionalized cyclopentene derivatives in optically active form. A one-pot tandem tetrahydrofuran ring cleavage followed by ring closing olefin metathesis also provided functionalized cyclopentenes in good yield.
Asymmetric multicomponent reactions: Diastereoselective synthesis of substituted pyrrolidines and prolines
Ghosh, Arun K.,Kulkarni, Sarang,Xu, Chun-Xiao,Fanwick, Phillip E.
, p. 4509 - 4511 (2007/10/03)
A novel diastereoselective synthesis of substituted pyrrolidines has been developed. Asymmetric multicomponent reactions of optically active phenyldihydrofuran, N-tosyl imino ester, and silane reagents in a one-pot operation afforded highly substituted py
