839712-12-8

Basic information

• Product Name: Cariprazine
• Synonyms: Urea, N'-[trans-4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N -diMethyl-;Cariprazine;N'-[trans-4-[2-[4-(2,3-Dichlorophenyl)-1-piperazinyl]ethyl]cyclohexyl]-N,N-dimethylurea;RGH 188
• CAS NO: 839712-12-8
• Molecular Formula: C₂₁H₃₂Cl₂N₄O
• Molecular Weight: 427.41098
• EINECS: 1592732-453-0
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals;Inhibitor;CARIPRAZINE and Impurities
• Mol File: 839712-12-8.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• Density: 1.24
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: Cariprazine(CAS DataBase Reference)
• NIST Chemistry Reference: Cariprazine(839712-12-8)
• EPA Substance Registry System: Cariprazine(839712-12-8)

Safety Data

• Hazardous Substances Data: 839712-12-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 839712-12-8 differently. You can refer to the following data:
1. Cariprazine is an orally active D2/D3 dopamine receptor antagonist. Cariprazine is an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression
2. Cariprazine is an orally active D2/D3 dopamine receptor antagonist (1,2,3). Cariprazine is an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression.

Definition

ChEBI: An N-alkylpiperazine that is N,N-dimethyl-N'-{trans-4-[2-(piperazin-1-yl)ethyl]cyclohexyl}urea substituted at position 4 on the piperazine ring by a 2,3-dichloroph nyl group. Used (as the hydrochloride salt) for treatment of schizophrenia and bipolar disorder.

Upstream product

• 791778-53-5 trans-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexane-1-amine 
• 119532-26-2 1-(2,3-dichlorophenyl)-piperazine hydrochloride 
• 1313279-47-8 trans-(4-cyanomethyl-cyclohexyl)-carbamic acid tert-butyl ester 
• 239074-29-4 trans (4-hydroxymethyl-cyclohexyl)-carbamic acid tert-butyl ester 
• 27960-59-4 trans-4-aminocyclohexanecarboxylic acid hydrochloric acid 
• 146307-51-9 methyl (1R,4R)-4-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate 
• 27514-08-5 N-(4-oxocyclohexyl)acetamide 
• 2901-44-2 trans-2-(4-acetamidocyclohexyl)acetic acid 
• 497856-35-6 N-methoxy-N-methyl-2-(p-nitrophenyl)acetamide 

Downstream Products

• 1083076-69-0 Cariprazine hydrochloride 

Relevant articles and documents

Preparation method of carlyrazide and intermediate compound

The present invention provides a method for preparing carlirazine and an intermediate compound. The preparation method of the present invention is simple, no need for high temperature and high pressure conditions and the use of a precious catalyst, cost savings, and the yield and purity of carilazine are high.

Cariprazine synthesis method

The invention provides a cariprazine synthesis method, which comprises the following steps: carrying out acylation on a compound (I) in a reaction solvent with a proper temperature and dimethylaminoformyl chloride into an aqueous solution of an inorganic alkali to obtain cariprazine (compound II), wherein the reaction formula is defined in the specification. According to the invention, the synthesis method overcomes the defects of long reaction time, large impurity, difficulty in purification and the like in the prior art, and provides a novel method with characteristics of rapid reaction, small impurity, easy purifying, high yield and suitable for commercial mass production, wherein the purity of the product can reach more than 99.0%.