791778-53-5

Basic information

• Product Name: Cyclohexanamine, 4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]-, trans-
• CAS NO: 791778-53-5
• Molecular Formula: C18H27Cl2N3
• Molecular Weight: 356.338
• Mol File: 791778-53-5.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Cyclohexanamine, 4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]-, trans-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanamine, 4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]-, trans-(791778-53-5)
• EPA Substance Registry System: Cyclohexanamine, 4-[2-[4-(2,3-dichlorophenyl)-1-piperazinyl]ethyl]-, trans-(791778-53-5)

Safety Data

• Hazardous Substances Data: 791778-53-5(Hazardous Substances Data)

Usage

Uses

trans-4-[2-[4-(2,3-Dichlorophenyl)piperazin-1-yl]ethyl]cyclohexanamine, is an impurity of Cariprazine (C183490), an orally active D2/D3 dopamine receptor antagonist (1,2,3). Cariprazine is an antipsychotic drug candidate for the potential treatment of schizophrenia, bipolar mania and depression.

Upstream product

• 4746-97-8 cyclohexanedione monoethylene ketal 
• 62141-26-8 ethyl 1,4-dioxaspiro[4.5]dec-8-ylacetate 
• 119532-26-2 1-(2,3-dichlorophenyl)-piperazine hydrochloride 
• 2093293-77-5 trans (2-(1-[4-(N-(tert-butoxycarbonyl))-amino]-cyclohexyl))ethyl 4-methylbenzenesulfonate 
• 223131-01-9 tert-butyl ((cis)-4-(hydroxymethyl)cyclohexyl)carbamate 
• 364385-64-8 cis-4-(tert-butoxycarbonylamino)cyclohexanecarboxylic acid methyl ester 
• 62456-15-9 methyl (1s,4s)-4-aminocyclohexane-1-carboxylate 
• 118785-97-0 cis-4-amino-cyclohexanecarboxylic acid hydrochloride 
• 1069120-41-7 ((cis)-4-((tert-butoxycarbonyl)amino)cyclohexyl)methyl methanesulfonate 
• 506427-91-4 tert-butyl (cis-4-(2-(4-(2,3-dichlorophenyl)piperazin-1-yl)ethyl)cyclohexyl)carbamate 
• 41202-77-1 1-(2,3-dichlorophenyl)piperazine 
• 847417-37-2 tert-butyl ((1s,4s)-4-(2-oxoethyl)cyclohexyl)carbamate 
• 327156-95-6 ((1s,4s)-4-((tert-butoxycarbonyl)amino)cyclohexyl)acetic acid 
• 1313279-47-8 trans-(4-cyanomethyl-cyclohexyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

A New and Practical Synthesis of Cariprazine through the Facile Construction of 2-[ trans -4-(3,3-Dimethylureido)cyclohexyl]acetic Acid

A new, practical, and improved synthetic route to cariprazine is described. The key step is the facile preparation of 2-[4-(3,3-dimethylureido)cyclohexyl]acetic acid in the trans configuration through direct recrystallization. The entire synthetic procedure was accomplished under mild conditions while avoiding tedious purification processes. The trans configuration of cariprazine was confirmed by X-ray crystallographic analysis.

Nitrogen-containing ring derivative regulator as well as preparation method and application thereof

The invention relates to a nitrogen-containing ring derivative regulator as well as a preparation method and an application thereof. In particular, the present invention relates to a compound represented by general formula (I), a preparation method thereof, a pharmaceutical composition containing the compound, and an application of the compound as a G-protein coupled receptor modulator in the treatment or prevention of central nervous system diseases and/or mental diseases.

Method for preparing medicinal carliflazine composition

The invention provides a medicinal high-purity carliflazine composition and a method for preparing the medicinal high-purity carliflazine composition. The preparation process of the medicinal carliprazine composition can obviously reduce the content of mo