839714-33-9

Usage

Uses

Used in Pharmaceutical Industry:
1-Isopropylpyrazole-5-boronic Acid is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its ability to form carbon-carbon and carbon-heteroatom bonds makes it an essential component in the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
1-Isopropylpyrazole-5-boronic Acid is used as a building block in the synthesis of agrochemicals, such as pesticides and herbicides. Its versatility in forming complex organic molecules contributes to the development of more effective and targeted agrochemicals for agricultural applications.
Used in Organic Synthesis:
1-Isopropylpyrazole-5-boronic Acid is used as a reagent in various organic synthesis processes. Its participation in Suzuki-Miyaura cross-coupling reactions allows for the efficient formation of biaryl compounds, which are important structural motifs in many organic molecules, including pharmaceuticals and agrochemicals.
Overall, 1-Isopropylpyrazole-5-boronic Acid plays a crucial role in the production of various important compounds, contributing to advancements in the fields of medicine and agriculture by enabling the synthesis of novel and improved pharmaceuticals and agrochemicals.

Upstream product

• 688-74-4 boric acid tributyl ester 
• 18952-87-9 1-isopropyl-1H-pyrazole 

Downstream Products

• 1162644-60-1 2'-fluoro-5-(2-isopropyl-2H-pyrazol-3-yl)-4'-methyl-biphenyl-3-carboxylic acid methyl ester 
• 839714-36-2 4-chloro-1-isopropyl-5-(2-methoxy-5-nitro-phenyl)-1H-pyrazole 
• 839714-32-8 4-bromo-1-isopropyl-5-(2-methoxy-5-nitrophenyl)-1H-pyrazole 
• 839714-31-7 3-(4-bromo-2-isopropyl-2H-pyrazol-3-yl)-4-methoxyphenylamine 
• 839714-35-1 3-(4-chloro-2-isopropyl-2H-pyrazol-3-yl)-4-methoxy-phenylamine 
• 839714-37-3 3-(2-isopropyl-2H-pyrazol-3-yl)-4-methoxy-phenylamine 

Relevant academic research and scientific papers

Discovery of 1-[3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxyphenyl]-3-(2, 4-difluorophenyl)urea (Nelotanserin) and Related 5-Hydroxytryptamine 2A Inverse Agonists for the Treatment of Insomnia

Insomnia affects a growing portion of the adult population in the U.S. Most current therapeutic approaches to insomnia primarily address sleep onset latency. Through the 5-hydroxytryptamine2A (5-HT2A) receptor, serotonin (5-HT) plays a role in the regulation of sleep architecture, and antagonists/ inverse-agonists of 5-HT2A have been shown to enhance slow wave sleep (SWS). We describe here a series of 5-HT2A inverse-agonists that when dosed in rats, both consolidate the stages of NREM sleep, resulting in fewer awakenings, and increase a physiological measure of sleep intensity. These studies resulted in the discovery of 1-[3-(4-bromo-2- methyl-2i/-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (Nelotanserin), a potent inverse-agonist of 5-HT2A that was advanced into clinical trials for the treatment of insomnia.

Pyrazole-substituted arylamides as P2X3 and P2X2/3 antagonists

Compounds of the formula I: or a pharmaceutically acceptable salt thereof, wherein, R1 is optionally substituted pyrazolyl, and R2, R3, R4, R5, R6, R7 and R8 are as defined herein. Also disclosed are methods of using the compounds for treating diseases associated with P2X3 and/or a P2X2/3 receptor antagonists and methods of making the compounds.

DIARYL AND ARYLHETEROARYL UREA DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE PROPHYLAXIS AND TREATMENT OF DISORDERS RELATED THERTO

The present invention relates to certain pyrazole derivatives of Formula (I) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and pharmaceutical compositions thereof are directed to