839730-33-5

Upstream product

• 839730-34-6 methyl 4,6-O-benzylidene-3-ethoxymethyl-2-keto-β-D-glucopyranoside 
• 71117-37-8 (2R,4aR,6R,7R,8R,8aS)-6-Methoxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine-7,8-diol 
• 3188-13-4 ethyl chloromethyl ether 

Downstream Products

• 839730-34-6 methyl 4,6-O-benzylidene-3-ethoxymethyl-2-keto-β-D-glucopyranoside 
• 7226-42-8 1,3,4,6-tetra-O-acetyl-2-deoxy-2-fluoro-α-D-glucopyranose 
• 86783-82-6 2-fluoro-D-glucose 
• 839730-44-8 methyl 4,6-O-benzylidene-3-O-ethoxymethyl-2-(20-oxa-18,18,19,19,21,21,22,22-octafluoro-docosanoic acid-22-sulfonate)-β-D-mannopyranoside 
• 839730-39-1 methyl 4,6-O-benzylidene-3-O-ethoxymethyl-2-(14-oxa-12,12,13,13,15,15,16,16-octafluoro-hexadecanoic acid-16-sulfonate)-β-D-mannopyranoside 
• 839730-41-5 methyl 4,6-O-benzylidene-3-O-ethoxymethyl-2-(8-oxa-6,6,7,7,9,9,10,10-octafluoro-decanoic acid-10-sulfonate)-β-D-mannopyranoside 
• 839730-42-6 methyl 4,6-O-benzylidene-3-O-ethoxymethyl-2-(6-oxa-4,4,5,5,7,7,8,8-octafluoro-octanoic acid-8-sulfonate)-β-D-mannopyranoside 
• 839730-43-7 methyl 4,6-O-benzylidene-3-O-ethoxymethyl-2-(20-oxa-18,18,19,19,21,21,22,22-octafluoro-16-iodo-docosanoic acid-22-sulfonate)-β-D-mannopyranoside 
• 839730-38-0 methyl 4,6-O-benzylidene-3-O-ethoxymethyl-2-(14-oxa-12,12,13,13,15,15,16,16-octafluoro-10-iodo-hexadecanoic acid-16-sulfonate)-β-D-mannopyranoside 
• 839730-40-4 methyl 4,6-O-benzylidene-3-O-ethoxymethyl-2-(8-oxa-6,6,7,7,9,9,10,10-octafluoro-4-iodo-decanoic acid-10-sulfonate)-β-D-mannopyranoside 
• 839730-37-9 methyl 4,6-O-benzylidene-3-O-ethoxymethyl-2-(5-iodooctafluoro-3-oxapentane sulfonate)-β-D-mannopyranoside 
• 839730-47-1 methyl 4,6-O-benzylidene-3-O-ethoxymethyl-2-deoxy-2-fluoro-β-D-mannopyranoside 
• 932397-64-3 methyl 4,6-O-benzylidene-3-O-ethoxymethyl-2-(1,1,2,2,3,3,4,4,4-nonafluoro-butane-sulfonate)-β-D-mannopyranoside 
• 839730-36-8 methyl 4,6-O-benzylidene-3-O-ethoxymethyl-β-D-mannopyranoside 

Relevant academic research and scientific papers

Synthesis of the positron-emitting radiotracer [18F]-2-fluoro-2- deoxy-d-glucose from resin-bound perfluoroalkylsulfonates

A new approach to the synthesis of 2-fluoro-2-deoxy-d-glucose (FDG, [ 19/18F]-3) is described, which employs supported perfluoroalkylsulfonate precursors 33-36, where the support consists of insoluble polystyrene resin beads. Treatment of these resins with [ 19F]fluoride ion afforded protected FDG [19F]-18 as the major product, and the identities of the main byproducts were determined. Acidic removal of the acetal protecting groups from [19F]-18 was shown to produce [19F]FDG. The method has been applied to the efficient radiosynthesis of the imaging agent [18F]FDG, and was shown to produce the radiochemical tracer in good radiochemical yield (average 73%, decay corrected). The Royal Society of Chemistry 2009.

A solid-phase route to 18F-labeled tracers, exemplified by the synthesis of [18F]2-fluoro-2-deoxy-D-glucose

(Chemical Equation Presented) Scintillating synthesis: 18F- Containing radiopharmaceuticals can be prepared by using [18F] fluoride ions to displace a sulfonate linker and release a radiotracer from a solid support (see scheme; EOM =

PRODUCTION OF 2-18F-2-DEOXY-D-GLUCOSE VIA SOLID-PHASE SYNTHESIS

The invention relates to a compound of formula (I): wherein P1, P2,P3, and P4 are each independently hydrogen or a protecting group; and n is an integer of from 2 to 20 and to the use of such compounds for the s