839730-41-5Relevant academic research and scientific papers
Synthesis of the positron-emitting radiotracer [18F]-2-fluoro-2- deoxy-d-glucose from resin-bound perfluoroalkylsulfonates
Brown, Lynda J.,Ma, Nianchun,Bouvet, Denis R.,Champion, Sue,Gibson, Alex M.,Hu, Yulai,Jackson, Alex,Khan, Imtiaz,Millot, Nicolas,Topley, Amy C.,Wadsworth, Harry,Wynn, Duncan,Brown, Richard C. D.
experimental part, p. 564 - 575 (2009/07/18)
A new approach to the synthesis of 2-fluoro-2-deoxy-d-glucose (FDG, [ 19/18F]-3) is described, which employs supported perfluoroalkylsulfonate precursors 33-36, where the support consists of insoluble polystyrene resin beads. Treatment of these resins with [ 19F]fluoride ion afforded protected FDG [19F]-18 as the major product, and the identities of the main byproducts were determined. Acidic removal of the acetal protecting groups from [19F]-18 was shown to produce [19F]FDG. The method has been applied to the efficient radiosynthesis of the imaging agent [18F]FDG, and was shown to produce the radiochemical tracer in good radiochemical yield (average 73%, decay corrected). The Royal Society of Chemistry 2009.
A solid-phase route to 18F-labeled tracers, exemplified by the synthesis of [18F]2-fluoro-2-deoxy-D-glucose
Brown, Lynda J.,Bouvet, Denis R.,Champion, Sue,Gibson, Alex M.,Hu, Yulai,Jackson, Alex,Khan, Imtiaz,Ma, Nianchun,Millot, Nicholas,Wadsworth, Harry,Brown, Richard C. D.
, p. 941 - 944 (2008/02/01)
(Chemical Equation Presented) Scintillating synthesis: 18F- Containing radiopharmaceuticals can be prepared by using [18F] fluoride ions to displace a sulfonate linker and release a radiotracer from a solid support (see scheme; EOM =
