840-80-2Relevant academic research and scientific papers
Antimicrobial activities of synthetic arylidine nicotinic and isonicotinic hydrazones
Hayat, Muhammad,Khan, Khalid Mohammed,Saeed, Sumayya,Salar, Uzma,Khan, Momin,Baig, Taimoor,Ahmad, Aqeel,Parveen, Shahnaz,Taha, Muhammad
, p. 1057 - 1067 (2018/10/31)
Background: Despite availability of variety of antibacterial agents, re-emergance of pathogenic bacteria is still a serious medical concern. Identification of new, safer, and selective antibacterial agents is the key interest in the medicinal chemistry research. Methods: A library of synthetic arylidene nicotinic and isonicotinic hydrazones (1-63) were investigated for antimicrobial activities. Results: A number of derivatives showed significant to moderate antimicrobial activities against Gram positive and Gram negative bacterial cultures. Few compounds also showed antifungal activity against fungal cultures. Minimum Inhibitory Concentration (MIC) was calculated for the most active compounds 1, 7, 11, 19, 34, 46, 50, 51, and 55 against gram positive and gram negative cultures. Conclusion: Newly identified compounds may serve as lead for future research in order to get the more powerful antibacterial agents.
Xanthine oxidase inhibitory activity of nicotino/isonicotinohydrazides: A systematic approach from in vitro, in silico to in vivo studies
Zafar, Humaira,Hayat, Muhammad,Saied, Sumayya,Khan, Momin,Salar, Uzma,Malik, Rizwana,Choudhary, M. Iqbal,Khan, Khalid Mohammed
, p. 2351 - 2371 (2017/04/03)
Change in life style and eating habits has led to an increased prevalence of hyperuricemia worldwide. The role of hyperuricemia is no more restricted to gout, but it has a central role in progression of CVD, hypertension, metabolic syndrome, and arthritis
MFA zeotype catalyst: A greener approach for the synthesis of INH azomethine scaffolds
Raghuvanshi, Devendra S.,Mahulikar, Pramod P.,Meshram, Jyotsna S.
, p. 48071 - 48078 (2015/06/16)
Herein, we are reporting the green and efficient synthesis of some pharmacologically important azomethine derivatives of isoniazide (INH) using Modified Fly Ash (MFA) as an excellent zeotic solid acid catalyst. The catalyst, by virtue of its terminal hydr
Thiazolidin-4-one, azetidin-2-one and 1,3,4-oxadiazole derivatives of isonicotinic acid hydrazide: Synthesis and their biological evaluation
Gilani, Sadaf J.,Khan, Suroor A.,Alam, Ozair,Singh, Vijender,Arora, Alka
experimental part, p. 1057 - 1067 (2012/02/05)
A series of thiazolidin-4-one (2a-h; 3a-h), azetidin-2-one (4a-h) and 1,3,4-oxadiazole (5a-h) derivatives of isoninicotinic acid hydrazide (INH) were synthesized in order to obtain new compounds with potential anti-inflammatory, analgesic, ulcerogenic and
Synthesis and anti-mycobacterial activity of (E)-N′-(monosubstituted-benzylidene)isonicotinohydrazide derivatives
Lourenco, Maria Cristina da Silva,Ferreira, Marcelle de Lima,de Souza, Marcus Vinicius Nora,Peralta, Monica Amado,Vasconcelos, Thatyana Rocha Alves,Henriques, Maria das Gracas M.O.
, p. 1344 - 1347 (2008/09/21)
A series of 22 (E)-N′-(monosubstituted-benzylidene)isonicotinohydrazide derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test and
Mechanistic differences between in vitro assays for hydrazone-based small molecule inhibitors of anthrax lethal factor
Hanna, M. Leslie,Tarasow, Theodore M.,Perkins, Julie
, p. 50 - 58 (2008/09/18)
A systematically generated series of hydrazones were analyzed as potential inhibitors of anthrax lethal factor. The hydrazones were screened using one UV-based and two fluorescence-based in vitro assays. The study identified several inhibitors with IC50 values in the micromolar range, and importantly, significant differences in the types of inhibition were observed with the different assays.
Synthesis and characterization of iron (II, III) complexes of 3-hydroxy-benzaldehyde isonicotinic acid hydrazone
Mallikarjuna Reddy,Anil Kumar,Mohan Raju,Manohara Murthy
, p. 1182 - 1186 (2007/10/03)
Fe(II) and Fe(III) complexes of 3-hydroxybenzaldehyde isonicotinic acid hydrazone (3-HBINAH) have been synthesized and characterized by elemental analyses, magnetic susceptibility, electronic, IR, ESR, Moessbauer and XRD studies. The IR spectral studies indicate that nitrogen of azomethine and the oxygen of carbonyl group of the ligand participate in coordination in both the complexes while giving no evidence for the presence of lattice, or coordinated water. The presence of unidentate sulphate, (NH4)+ ion in iron(II) complex and Fe-CI bonds in iron(III) complex are also indicated. The Moessbauer, electronic and electron spin resonance spectral studies and magnetic susceptibility measurements suggest octahedral geometry probably with a slight distortion to both the complexes. The X-ray powder diffraction data indicate that both the Fe(II) and Fe(III) complexes belong to the tetragonal crystal systems.
