84000-01-1

Basic information

• Product Name: NALPHA-9-Fluorenylmethoxycarbonyl-L-pipecolinic acid
• Synonyms: NALPHA-9-Fluorenylmethoxycarbonyl-L-pipecolinic acid
• CAS NO: 84000-01-1
• Molecular Formula: C21H21NO4
• Molecular Weight: 351.39574
• Product Categories: Amino Acids
• Mol File: 84000-01-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: NALPHA-9-Fluorenylmethoxycarbonyl-L-pipecolinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: NALPHA-9-Fluorenylmethoxycarbonyl-L-pipecolinic acid(84000-01-1)
• EPA Substance Registry System: NALPHA-9-Fluorenylmethoxycarbonyl-L-pipecolinic acid(84000-01-1)

Safety Data

• Hazardous Substances Data: 84000-01-1(Hazardous Substances Data)

Upstream product

• 72-18-4 L-valine 
• 50-00-0 formaldehyd 
• 82911-80-6 N-Fmoc-valine methyl ester 
• 68858-20-8 Fmoc-Val-OH 

Downstream Products

• 103478-58-6 Fmoc-N-methylvaline 
• 84000-11-3 N-Fmoc-N-methyl-L-valine 

Relevant articles and documents

Fungal Dioxygenase AsqJ Is Promiscuous and Bimodal: Substrate-Directed Formation of Quinolones versus Quinazolinones

Previous studies showed that the FeII/α-ketoglutarate dependent dioxygenase AsqJ induces a skeletal rearrangement in viridicatin biosynthesis in Aspergillus nidulans, generating a quinolone scaffold from benzo[1,4]diazepine-2,5-dione substrates. We report that AsqJ catalyzes an additional, entirely different reaction, simply by a change in substituent in the benzodiazepinedione substrate. This new mechanism is established by substrate screening, application of functional probes, and computational analysis. AsqJ excises H2CO from the heterocyclic ring structure of suitable benzo[1,4]diazepine-2,5-dione substrates to generate quinazolinones. This novel AsqJ catalysis pathway is governed by a single substituent within the complex substrate. This unique substrate-directed reactivity of AsqJ enables the targeted biocatalytic generation of either quinolones or quinazolinones, two alkaloid frameworks of exceptional biomedical relevance.

Fluorenylmethoxycarbonyl-N-methylamino acids synthesized in a flow tube-in-tube reactor with a liquid-liquid semipermeable membrane

Both steps of the N-methylation of 9-fluorenylmethoxycarbonyl (Fmoc) amino acids were carried out in a microstructured tube-in-tube reactor equipped with a semipermeable Teflon AF 2400 membrane as the inner tubing. In the first step, gaseous formaldehyde

Mild regeneration of the carboxylic group of amino acid alkyl esters by aqueous methanolic sodium hydrogen carbonate via 5-oxazolidinones

A simple racemization-free procedure allows the regeneration of the carboxylic acid group of amino acid alkyl esters by way of an intermediate 5-oxazolidinone which is hydrolyzed by treatment with sodium hydrogen carbonate in aqueous methanol.