84000-11-3

Basic information

• Product Name: Fmoc-N-methyl-L-valine
• Synonyms: FMOC-MEVAL-OH;FMOC-N-ALPHA-METHYL-L-VALINE;FMOC-N-ME-VALINE;FMOC-N-ME-VAL-OH;FMOC-N-METHYL-L-VALINE;FMOC-N-ME-L-VAL-OH;FMOC-L-MEVAL-OH;N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-ALPHA-METHYL-L-VALINE
• CAS NO: 84000-11-3
• Molecular Formula: C₂₁H₂₃NO₄
• Molecular Weight: 353.41
• Product Categories: Amino Acids;Valine [Val, V];N-Methyl Amino Acids;Fmoc-Amino acid series
• Mol File: 84000-11-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 187-190 °C
• Boiling Point: 527.6 °C at 760 mmHg
• Flash Point: 272.9 °C
• Appearance: White/Powder
• Density: 1.214 g/cm³
• Vapor Pressure: 5.83E-12mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: 2-8°C
• PKA: 3.92±0.10(Predicted)
• Water Solubility: Slightly soluble in water and dimethyl formamide.
• BRN: 4560212
• CAS DataBase Reference: Fmoc-N-methyl-L-valine(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc-N-methyl-L-valine(84000-11-3)
• EPA Substance Registry System: Fmoc-N-methyl-L-valine(84000-11-3)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 84000-11-3(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

Uses

N-Fmoc-N-methyl-L-valine is used as enzyme substrates and reagents, culture media additives, dyes, stains and indicators. It is also involved in the preparation of N-methylated peptides.

InChI:InChI=1/C21H23NO4/c1-13(2)19(20(23)24)22(3)21(25)26-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,13,18-19H,12H2,1-3H3,(H,23,24)/t19-/m0/s1

Upstream product

• 67-56-1 methanol 
• 72-18-4 L-valine 
• 28920-43-6 (fluorenylmethoxy)carbonyl chloride 
• 68858-20-8 Fmoc-Val-OH 
• 1220527-59-2 N-Fmoc-N-methyl-L-valine benzhydryl ester 
• 1208119-51-0 N-methyl-N-nosyl-L-valine phenacyl ester 
• 186581-53-3 diazomethane 
• 270073-00-2 3-methyl-2-(4-nitrophenylsulphonamido)butanoic acid 
• 84000-01-1 9H-fluoren-9-ylmethyl (S)-4-isopropyl-5-oxo-1,3-oxazolidine-3-carboxylate 

Downstream Products

• 1360075-55-3 H-Asp(OtBu)-D-Tyr(tBu)-MeVal-Arg(Pbf)-Gly-OH 
• 1360075-54-2 cyclo(Asp(OtBu)-D-Tyr(tBu)-MeVal-Arg(Pbf)-Gly) 
• 1579990-03-6 C₅₉H₉₂N₈O₁₁ 

Relevant articles and documents

A total synthesis of a highly N-methylated cyclodepsipeptide [2S,3S-Hmp]-aureobasidin L using solid-phase methods

[2S,3S-Hmp]-Aureobasidin L 2 has been successfully synthesised through a combination of solution- and solid-phase peptide synthesis. All of the Fmoc-protected residues including a depsidipeptide, Fmoc-MeVal-Hmp-OH, were prepared in solution phase. Chain e

A preparation of N-Fmoc-N-methyl-α-amino acids and N-nosyl-N-methyl-α-amino acids

A convenient route for the synthesis of lipophilic N-Fmoc-N-methyl-α- amino acids and N-nosyl-N-methyl-α-amino acids, interesting building blocks to be used for the preparation of N-methylated peptides, is presented. Both nosyl- and Fmoc-protected monomer

Solid-phase synthesis of N-nosyl- and N-Fmoc-N-methyl-α-amino acids

(Chemical Equation Presented) We report here a convenient and simple solid-phase synthesis of N-nosyl-N-methyl-α-amino acids and N-Fmoc-N-methyl-α-amino acids, important building blocks for the synthesis of conformationally restricted and protease-resista