84048-08-8

Upstream product

• 92445-64-2 {(2R,3S)-3-Ethyl-1-[(4-nitro-benzylcarbamoyl)-methyl]-4-oxo-azetidin-2-yl}-thioacetic acid S-phenyl ester 
• 92445-59-5 {(2R,3S)-3-Ethyl-1-[(4-nitro-benzylcarbamoyl)-methyl]-4-oxo-azetidin-2-yl}-acetic acid benzyl ester 
• 83997-55-1 (3R,4R)-3-ethyl-4-<3-diazo-2-oxo-3-<<(p-nitrobenzyl)oxy>carbonyl>propyl>-2-azetidinone 
• 92445-58-4 (2S,3R)-3-Amino-2-ethyl-pentanedioic acid 5-benzyl ester 
• 16631-50-8 diethyl 2-ethyl-3-oxoglutarate 
• 92445-66-4 ((3S,4R)-3-Ethyl-2-oxo-4-phenylsulfanylcarbonylmethyl-azetidin-1-yl)-acetic acid 4-nitro-benzyl ester 
• 92445-56-2 (2S,3R)-3-Benzyloxycarbonylamino-2-ethyl-pentanedioic acid 
• 92445-54-0 (2S,3R)-3-Amino-2-ethyl-pentanedioic acid 

Downstream Products

• 71730-34-2 (5RS,6RS)-p-nitrobenzyl 3-(2-acetamidoethylthio)-6-ethyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate 

Relevant academic research and scientific papers

A New Synthetic Approach to the Carbapenem Antibiotic PS-5 from Ethyl (S)-3-Hydroxybutanoate

A new synthetic route to the PS-5 key precursor is described which involves the fully stereocontrolled transformation of the optically active 2-azetidinone derivative easily obtainable from ethyl (S)-3-hydroxybutanoate.

A Short and Stereoselective Synthesis of the Carbapenem Antibiotic PS-5

The benzyl ester (3) and p-nitrobenzyl ester (PNB ester) (4) of the antibiotic PS-5 and the bis-protected PS-6 (5) were stereoselectively synthesised by application of the new carbon-carbon bond formation reaction at the C-4-position of 4-acetoxy-3-ethyl-