840481-77-8

Usage

Class of compound

imidazole carboxylic acid derivative

Appearance

white to off-white crystalline powder

Stability

stable under normal temperatures and pressures

Storage

should be stored in a cool, dry place away from heat and sources of ignition

Uses

commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various pharmaceuticals and bioactive compounds.

Upstream product

• 71759-89-2 4-iodoimidazole 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 952493-88-8 N,N-diethyl-2-(5-iodoimidazol-1-ylmethyl)benzamide 
• 1316228-39-3 C₁₇H₁₉N₅O₂ 
• 1049634-33-4 C₂₈H₃₄N₄O₄ 

Relevant academic research and scientific papers

Rapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling-TMS-deprotection-CuAAC sequence

The one-pot, three-component Sonogashira coupling-TMS-deprotection-CuAAC ("click") sequence is the key reaction for the rapid synthesis of triazolyl substituted N-Boc protected NH-heterocycles, such as indole, indazole, 4-, 5-, 6-, and 7-azaindoles, 4,7-diazaindole, 7-deazapurines, pyrrole, pyrazole, and imidazole. Subsequently, the protective group was readily removed to give the corresponding triazolyl derivatives of these tremendously important NH-heterocycles. All compounds have been tested in a broad panel of kinase assays. Several compounds, 8f, 8h, 8k, and 8l, have been shown to inhibit the kinase PDK1, a target with high oncology relevance, and thus they are promising lead structures for the development of more active derivatives. The X-ray structure analysis of compound 8f in complex with PDK1 has revealed the detailed binding mode of the molecule in the kinase. The Royal Society of Chemistry 2011.

SUBSTITUTED BENZOTHIOPHENE COMPOUNDS AND USES THEREOF

Disclosed are compounds of the formula (I), wherein R1, R2, R3 and R4 are described herein, which are active as anti-inflammatory agents. Also disclosed are methods of using and making such compounds.