840506-46-9

Basic information

• Product Name: Alanine, N-[chloro(4-chlorophenoxy)phosphinyl]-2-methyl-, methyl ester
• CAS NO: 840506-46-9
• Molecular Formula: C11H14Cl2NO4P
• Molecular Weight: 326.116
• Mol File: 840506-46-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Alanine, N-[chloro(4-chlorophenoxy)phosphinyl]-2-methyl-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Alanine, N-[chloro(4-chlorophenoxy)phosphinyl]-2-methyl-, methyl ester(840506-46-9)
• EPA Substance Registry System: Alanine, N-[chloro(4-chlorophenoxy)phosphinyl]-2-methyl-, methyl ester(840506-46-9)

Safety Data

• Hazardous Substances Data: 840506-46-9(Hazardous Substances Data)

Upstream product

• 84758-55-4 N-(tert-butoxycarbonyl)-α-methylalanine methyl ester 
• 15028-41-8 methyl 2-aminoisobutyrate hydrochloride 
• 772-79-2 4-chlorophenylphosphorodichloridate 

Downstream Products

• 914912-07-5 5-O-(4-chlorophenyl methoxydimethylglycinylphosphate)-(2-C-methyl-β-D-ribofuranosyl)cytosine 

Relevant articles and documents

6-Hydrazinopurine 2′-methyl ribonucleosides and their 5′-monophosphate prodrugs as potent hepatitis C virus inhibitors

A series of 6-hydrazinopurine 2′-methyl ribonucleosides was synthesized and tested for its inhibitory activity against the hepatitis C virus (HCV). The lack of antiviral activity of these nucleosides was associated with a poor affinity for adenosine kinase, which prompted us to synthesize several of their 5′-monophosphate prodrugs. Some of these prodrugs exhibited more than 1000-fold improvement in anti-HCV activity when compared to their parent nucleosides (EC50 of 24 nM vs 92 μM for the parent).

CHEMICAL COMPOUNDS

Phosphoramidate derivatives of nucleotides and their use in the treatment of cancer are described. The base moieties of, for example, each of deoxyuridine, cytarabine, gemcitabine and citidine may be substituted at the 5-position. The phosphoramidate moiety has attached to the P atom an aryl-O moiety and an α-amino acid moiety. The α-amino acid moiety may correspond to or be derived from either a naturally occurring or a non-naturally occurring amino acid.