914912-07-5Relevant academic research and scientific papers
PHOSPHORAMIDATE PRODRUGS FOR TREATMENT OF VIRAL INFECTION
-
Page/Page column 20-21, (2008/06/13)
The invention concerns 2'-methyl ribonucleotide phosphoramidates which are neutral prodrugs which are converted in vivo to 2'- methyl ribonucleotide triphosphates. These compounds are useful in the treatment of viral infection. Of particular interest are prodrugs of a methylsulfonylhydrazinyl purine 2'-methyl nucleotide triphosphate: 2'methyl- N6-alkyl-N6- (N-methylsulfonamide) adenosine triphosphate and its 2-amino derivative.
