840529-66-0

Basic information

• Product Name: Benzenesulfonamide, N-[(R)-(4-chlorophenyl)phenylmethyl]-4-nitro-
• CAS NO: 840529-66-0
• Molecular Formula: C19H15ClN2O4S
• Molecular Weight: 402.858
• Mol File: 840529-66-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-[(R)-(4-chlorophenyl)phenylmethyl]-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-[(R)-(4-chlorophenyl)phenylmethyl]-4-nitro-(840529-66-0)
• EPA Substance Registry System: Benzenesulfonamide, N-[(R)-(4-chlorophenyl)phenylmethyl]-4-nitro-(840529-66-0)

Safety Data

• Hazardous Substances Data: 840529-66-0(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 3262-89-3 triphenylboroxine 
• 260997-38-4 C₁₃H₉ClN₂O₄S 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 260997-38-4 N-(4-chloro-benz-(E)-ylidene)-4-nitro-benzenesulfonamide 
• 63160-16-7 4-nitro-N-(phenylmethylene)benzenesulfonamide 
• 7519-91-7 tris(4-chlorophenyl)boroxine 
• 100-52-7 benzaldehyde 
• 63160-16-7 4-nitro-N-[(1E)-phenylmethylidene]benzene-1-sulfonamide 
• 934-56-5 trimethyl(phenyl)stannane 

Relevant articles and documents

Highly Enantioselective Ferrocenyl Palladacycle-Acetate Catalysed Arylation of Aldimines and Ketimines with Arylboroxines

Benzylic N-substituted stereocenters constitute a frequent structural motif in drugs. Their highly enantioselective generation is hence of technical importance. An attractive strategy is the arylation of imines with organoboron reagents. Chiral Rh complexes have reached a high level of productivity for this reaction type. In this article we describe that an electron rich PdIIcatalyst also performs well in the arylation of aldimines, comparable to the best Rh catalysts. The ferrocenyl palladacycle-acetate catalyst allows for a broad substrate scope and very high enantioselectivities. Commonly observed side reactions like aryl–aryl homocouplings and imine hydrolysis could be blocked. Mechanistic studies implicate that a) the acetate ligand is crucial for transmetallation, b) the active catalyst is most likely a palladacycle-OAc monomer, c) the rate limiting step is probably the product release. By added KOAc the arylation could also be applied to ketimines.

Exogenous-Base-Free Palladacycle-Catalyzed Highly Enantioselective Arylation of Imines with Arylboroxines

Enantiomerically pure benzylic amines are important for the development of new drugs. A readily accessible planar-chiral ferrocene-derived palladacycle is shown to be a highly efficient catalyst for the formation of N-substituted benzylic stereocenters; t

Electronic and steric tuning of chiral diene ligands for rhodium-catalyzed asymmetric arylation of imines

Rhodium-catalyzed asymmetric arylation of imines using electronically and sterically-modified chiral diene ligands gave the corresponding diarylmethylamines in high yield and with high enantioselectivity using just 0.3 mol% of catalyst.