84064-15-3Relevant articles and documents
Preparation and synthetic applications of N-(α,β-unsaturated acyl)-α-amino acid derivatives
Katritzky, Alan R.,Gyanda, Reena,Meher, Nabin K.,Song, Yuming
experimental part, p. 1249 - 1259 (2010/10/03)
N-(α,β-Unsaturated acyl)-α-amino acids, amides and esters are structural motifs of many biologically active natural products. An alternate and advantageous approach for the synthesis of N-(α,β-unsaturated acyl)-α-amino acid derivatives is developed via ac
Characterization of the binding properties of SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone
Kiviranta, Paeivi H.,Salo, Heikki S.,Leppaenen, Jukka,Rinne, Valtteri M.,Kyrylenko, Sergiy,Kuusisto, Erkki,Suuronen, Tiina,Salminen, Antero,Poso, Antti,Lahtela-Kakkonen, Maija,Wallen, Erik A.A.
, p. 8054 - 8062 (2008/12/23)
SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone were studied. This backbone has been developed in our group, and it is derived from a compound originally found by virtual screening. In addition, compounds with a smaller 3-phenylpropenoic acid tryptamide backbone were also included in the study. Binding modes for the new compounds and the previously reported compounds were analyzed with molecular modelling methods. The approach, which included a combination of molecular dynamics, molecular docking and cluster analysis, showed that certain docking poses were favourable despite the conformational variation in the target protein. The N-(3-phenylpropenoyl)-glycine tryptamide backbone is also a good backbone for SIRT2 inhibitors, and the series of compounds includes several potent SIRT2 inhibitors.
