84099-69-4Relevant academic research and scientific papers
Preparation of 2-Amino-4(3H)-oxopyrimidothiazines (5-Thiapterins) and Their Evaluation as Cofactors for Phenylalanine Hydroxylase
Henrie, Robert N.,Lazarus, Robert A.,Benkovic, Stephen J.
, p. 559 - 563 (1983)
Reaction of diethyl chloromalonate with β-mercapto amines, 9, gave 1,4-thiazin-3-ones, 10, which were alkylated exclusively at the lactam oxygen with triethyloxonium tetrafluoroborate and subsequently condensed with guanidine to give the first reported 5-
