Journal of Medicinal Chemistry p. 559 - 563 (1983)
Update date:2022-08-04
Topics:
Henrie, Robert N.
Lazarus, Robert A.
Benkovic, Stephen J.
Reaction of diethyl chloromalonate with β-mercapto amines, 9, gave 1,4-thiazin-3-ones, 10, which were alkylated exclusively at the lactam oxygen with triethyloxonium tetrafluoroborate and subsequently condensed with guanidine to give the first reported 5-
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(1984)
