Preparation of 2-Amino-4(3H)-oxopyrimidothiazines (5-Thiapterins) and Their Evaluation as Cofactors for Phenylalanine Hydroxylase

DOI: 10.1021/jm00358a019

Source and publish data:

Journal of Medicinal Chemistry p. 559 - 563 (1983)

Update date:2022-08-04

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Authors:

Henrie, Robert N.

Lazarus, Robert A.

Benkovic, Stephen J.

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Article abstract of DOI:10.1021/jm00358a019

Reaction of diethyl chloromalonate with β-mercapto amines, 9, gave 1,4-thiazin-3-ones, 10, which were alkylated exclusively at the lactam oxygen with triethyloxonium tetrafluoroborate and subsequently condensed with guanidine to give the first reported 5-

Full text of DOI:10.1021/jm00358a019

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