84104-89-2

Basic information

• Product Name: 2-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-1-(1-methylethyl)-3-nitro-, (4bS,8aS)-
• Synonyms: 2-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-1-(1-methylethyl)-3-nitro-, (4bS,8aS)-
• CAS NO: 84104-89-2
• Molecular Formula: C₂₀H₂₉NO₃
• Molecular Weight: 0
• Mol File: 84104-89-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-1-(1-methylethyl)-3-nitro-, (4bS,8aS)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-1-(1-methylethyl)-3-nitro-, (4bS,8aS)-(84104-89-2)
• EPA Substance Registry System: 2-Phenanthrenol, 4b,5,6,7,8,8a,9,10-octahydro-4b,8,8-trimethyl-1-(1-methylethyl)-3-nitro-, (4bS,8aS)-(84104-89-2)

Safety Data

• Hazardous Substances Data: 84104-89-2(Hazardous Substances Data)

Upstream product

• 511-15-9 trans-totarol 

Downstream Products

• 84104-92-7 12-nitro-13-methoxytotara-8,11,13-triene 
• 84104-88-1 totara-8,11,13-triene-12,13-diol dibenzoate 
• 294191-20-1 12-acetamido-13-acetoxytotara-8,11,13-triene 
• 294191-29-0 12-acetamidototara-8,11,13-trien-13-ol 
• 84104-93-8 12-amino-13-methoxytotara-8,11,13-triene 
• 84104-87-0 (4aS,10aS)-1,2,3,4,4a,9,10,10a-octahydro-6,7-dihydroxy-8-isopropyl-1,1,1,4a-trimethylphenanthrene 
• 51847-85-9 13-methoxytotara-8,11,13-trien-12-ol 
• 51905-87-4 12-aminototara-8,11,13-trien-13-ol 

Relevant articles and documents

The synthesis and antibacterial activity of totarol derivatives. Part 2: Modifications at C-12 and O-13

Alterations of the C-12 and C-13 aromatic ring substituents of totarol (1) afforded the series of derivatives 2-14, and introduction of substituents at C-12 gave exclusively 2a-14a. The majority of these analogues were tested in vitro against the following organisms: β-lactamase-positive and high level gentamycin-resistant Enterococcus faecalis, penicillin-resistant Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus (MRSA), and multiresistant Klebsiella pneumoniae. The results were evaluated in terms of structure-activity relationship which reveals that: (a) the phenolic moiety at C-13, in general, is essential for antibacterial activity at 32 μg/mL against Gram-positive species, and (b) derivatization at C-12 has an undesirable effect on the antibacterial activity of this class of compounds, while (c) all compounds tested are ineffective against the Gram-negative Klebsiella pneumoniae. Copyright (C) 2000 Elsevier Science Ltd.