84104-92-7

Basic information

• Product Name: Phenanthrene, 1,2,3,4,4a,9,10,10a-octahydro-7-methoxy-1,1,4a-trimethyl-8-(1-methylethyl)-6-nitro-, (4aS,10aS)-
• Synonyms: Phenanthrene, 1,2,3,4,4a,9,10,10a-octahydro-7-methoxy-1,1,4a-trimethyl-8-(1-methylethyl)-6-nitro-, (4aS,10aS)-
• CAS NO: 84104-92-7
• Molecular Formula: C21H31 N O3
• Molecular Weight: 0
• Mol File: 84104-92-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Phenanthrene, 1,2,3,4,4a,9,10,10a-octahydro-7-methoxy-1,1,4a-trimethyl-8-(1-methylethyl)-6-nitro-, (4aS,10aS)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenanthrene, 1,2,3,4,4a,9,10,10a-octahydro-7-methoxy-1,1,4a-trimethyl-8-(1-methylethyl)-6-nitro-, (4aS,10aS)-(84104-92-7)
• EPA Substance Registry System: Phenanthrene, 1,2,3,4,4a,9,10,10a-octahydro-7-methoxy-1,1,4a-trimethyl-8-(1-methylethyl)-6-nitro-, (4aS,10aS)-(84104-92-7)

Safety Data

• Hazardous Substances Data: 84104-92-7(Hazardous Substances Data)

Upstream product

• 84104-94-9 12-bromo-13-methoxytotara-8,11,13-triene 
• 511-15-9 trans-totarol 
• 84104-89-2 12-nitrototara-8,11,13-trien-13-ol 
• 74-88-4 methyl iodide 
• 15340-83-7 13-methoxy-totara-8,11,13-triene 

Downstream Products

• 84104-93-8 12-amino-13-methoxytotara-8,11,13-triene 
• 51847-85-9 13-methoxytotara-8,11,13-trien-12-ol 

Relevant articles and documents

The synthesis and antibacterial activity of totarol derivatives. Part 2: Modifications at C-12 and O-13

Alterations of the C-12 and C-13 aromatic ring substituents of totarol (1) afforded the series of derivatives 2-14, and introduction of substituents at C-12 gave exclusively 2a-14a. The majority of these analogues were tested in vitro against the following organisms: β-lactamase-positive and high level gentamycin-resistant Enterococcus faecalis, penicillin-resistant Streptococcus pneumoniae, methicillin-resistant Staphylococcus aureus (MRSA), and multiresistant Klebsiella pneumoniae. The results were evaluated in terms of structure-activity relationship which reveals that: (a) the phenolic moiety at C-13, in general, is essential for antibacterial activity at 32 μg/mL against Gram-positive species, and (b) derivatization at C-12 has an undesirable effect on the antibacterial activity of this class of compounds, while (c) all compounds tested are ineffective against the Gram-negative Klebsiella pneumoniae. Copyright (C) 2000 Elsevier Science Ltd.