84118-68-3Relevant academic research and scientific papers
Palladium-catalyzed dehydrogenative β-arylation of simple saturated carbonyls by aryl halides
Gandeepan, Parthasarathy,Rajamalli,Cheng, Chien-Hong
, p. 4485 - 4489 (2014)
(Chemical Equation Presented) A versatile palladium-catalyzed synthesis of highly substituted α,β-unsaturated carbonyl compounds has been developed. In contrast to the known Heck-type coupling reaction of unsaturated carbonyl compounds with aryl halides, the present methodology allows the use of stable and readily available saturated carbonyl compounds as the alkene source. In addition, the reaction proceeds well with low catalyst loadings and does not require any expensive metal oxidants or ligands. A variety of saturated aldehydes, ketones, and esters are compatible for the reaction with aryl halides under the developed reaction conditions to afford α,β-unsaturated carbonyl compounds in good to excellent yields. A possible reaction mechanism involves a palladium-catalyzed dehydrogenation followed by Heck-type cross couplings.
Palladium-Catalyzed Acylation of Unsaturated Halides by Anions of Enol Ethers
Russell, Charles E.,Hegedus, Louis S.
, p. 943 - 949 (2007/10/02)
Zinc salts of enol ether anions are coupled to aryl and alkenyl halides by using palladium catalysts, effecting a direct acetylation of aryl and alkenyl halides.Zinc salts of allenic ethers are coupled with aryl and alkenyl halides under similar conditions to give α,β-unsaturated ketones, the allenic ether serving as a source of the acryloyl group.Allenic ethers were γ arylated in a palladium-catalyzed coupling with aryl halides to give β,β-diaryl-α,β-unsaturated aldehydes.
