84126-73-8Relevant academic research and scientific papers
Acridone derivatives: Design, synthesis, and inhibition of breast cancer resistance protein ABCG2
Boumendjel, Ahcene,Macalou, Sira,Ahmed-Belkacem, Abdelhakim,Blanc, Madeleine,Di Pietro, Attilio
, p. 2892 - 2897 (2007/10/03)
The breast cancer resistance protein (BCRP, ABCG2) is among the latest discovered ABC proteins to be involved in MDR phenotype and for which only few inhibitors are known. In continuing our program aimed at discovering efficient multidrug resistance modul
Potential antitumor agents. 38. 3-Substituted 5-carboxamido derivatives of amsacrine
Denny,Atwell,Baguley
, p. 1619 - 1625 (2007/10/02)
The synthesis and biological evaluation of a series of 3-substituted 5-carboxamido derivatives of amsacrine (m-AMSA) are described. This series was developed as the result of previous quantitative structure-activity relationship (QSAR) studies of the antitumor activity of 9-anilinoacridine derivatives. In agreement with these studies, this class of compounds, possessing a variety of small nonpolar groups at the 3-position, together with very hydrophilic carboxamido groups at the 5-position, have high in vivo activity against animal leukemia models.
