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Usage

General Description

6-Chloro-N-isobutyl-2-methylpyrimidin-4-amine is a chemical compound used in the synthesis of pharmaceuticals and agrochemicals. It belongs to the class of pyrimidine derivatives, which are important building blocks in the development of various drugs and crop protection products. 6-chloro-N-isobutyl-2-MethylpyriMidin-4-aMine is a potential intermediate in the production of fungicides and herbicides, as well as in the development of new therapeutic agents. Its chemical structure and properties make it a valuable tool for researchers and manufacturers in the pharmaceutical and agricultural industries.

Upstream product

• 1780-26-3 2,4-dichloro-2-methylpyrimidine 
• 78-81-9 isobutylamine 
• 1194-22-5 2-methyl-4,6-dihydroxypyrimidine 

Relevant academic research and scientific papers

Synthesis, molecular modeling and biological activity of methyl and thiomethyl substituted pyrimidines as corticotropin releasing hormone type 1 antagonists

Four small, targeted libraries of differentially substituted amino pyrimidines were synthesized in moderate to good yields. Excellent regiochemistry was observed for substitution at C2/C4 with selectivity >50 : 1 noted. All analogues were screened for their ability to interact with CRH 1 and CRH2 receptors. In all instances only poor agonistic and/or antagonistic behaviour was noted at CRH2. However, several compounds were potent and selective CRH1 antagonists, most notably 13a K1 = 39 nM. Additionally we have utilized these data and that recently reported by others to refine our original CRH1 pharmacophore (J. Med. Chem., 1999, 42, 2351-2357).