841296-15-9Relevant academic research and scientific papers
INHIBITORS OF ENL/AF9 YEATS
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Paragraph 00203-00204, (2021/06/26)
Methods and compositions for treating leukemia are disclosed. Acylated 6-aminoindoles, acylated 6-aminopyrrolopyridines and acylated 3-aminopyrrolo[3,2-c]pyridazines of the following formula inhibit ENL/AF9 YEATS and are therefore useful for treating leukemia.
SMALL MOLECULE INHIBITION OF SULFOTRANSFERASE SULT1A3
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Paragraph 0072, (2020/07/08)
Provided herein are small molecule compounds and methods inhibiting human sulfotransferase 1A3 (SULT1A3) using these small molecule compounds. Methods of manufacturing and treatment are also disclosed.
Gold(I)-catalyzed unprecedented rearrangement reaction between 2-aminobenzaldehydes with propargyl amines: An expedient route to 3-aminoquinolines
Patil, Nitin T.,Raut, Vivek S.,Shinde, Valmik S.,Gayatri, Gaddamanugu,Sastry, G. Narahari
supporting information; experimental part, p. 5530 - 5535 (2012/05/21)
Access to aminoquinolines: A gold(I)-catalyzed unprecedented rearrangement reaction between 2-aminobenzaldehydes with propargyl amine was studied. The study provided, for the first time, direct access to 3-aminoquinolines in one step starting from readily available starting materials (see scheme). Elegantly designed experiments were employed to unravel the mechanism of this unprecedented rearrangement, which are corroborated by DFT calculations.
Novel CGRP receptor antagonists from central amide replacements causing a reversal of preferred chirality
Wood, Michael R.,Schirripa, Kathy M.,Kim, June J.,Bednar, Rodney A.,Fay, John F.,Bruno, Joseph G.,Moore, Eric L.,Mosser, Scott D.,Roller, Shane,Salvatore, Christopher A.,Vacca, Joseph P.,Selnick, Harold G.
scheme or table, p. 6827 - 6830 (2011/01/04)
A previously utilized quinoline-for-N-phenylamide replacement strategy was employed against a central amide in a novel class of CGRP receptor antagonists. A unique and unexpected substitution pattern was ultimately required to maintain reasonable affinity
α-amination of nitrogen heterocycles: Ring-fused aminals
Zhang, Chen,De, Chandra Kanta,Mal, Rudrajit,Seidel, Daniel
, p. 416 - 417 (2008/09/20)
Aromatic aminoaldehydes react with cyclic amines to produce ring-fused aminals under thermal conditions. This process is applied to two-step syntheses of the quinazolinone alkaloids deoxyvasicinone and rutaecarpine. Copyright
BICYCLIC IMIDAZOL DERIVATIVES AGAINST FLAVIVIRIDAE
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Page/Page column 126, (2008/06/13)
Disclosed are compounds, compositions and methods for treatingFlaviviridae family virus infections.
