841303-92-2Relevant academic research and scientific papers
Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors
Zhao, Zhijian,Leister, William H.,Robinson, Ronald G.,Barnett, Stanley F.,Defeo-Jones, Deborah,Jones, Raymond E.,Hartman, George D.,Huff, Joel R.,Huber, Hans E.,Duggan, Mark E.,Lindsley, Craig W.
, p. 905 - 909 (2007/10/03)
This letter describes the discovery of a novel series of dual Akt1/Akt2 kinase inhibitors, based on a 2,3,5-trisubstituted pyridine scaffold. Compounds from this series, which contain a 5-tetrazolyl moiety, exhibit more potent inhibition of Akt2 than Akt1.
