335649-85-9

Upstream product

• 59-31-4 2-hydroxyquinoline 
• 612-62-4 2-Chloroquinoline 
• 128676-85-7 2-chloro-3-iodo-quinoline 
• 950856-36-7 3-iodoquinoline-1-oxide 
• 79476-07-6 3-Iodoquinoline 
• 580-17-6 3-aminoquinoline 
• 529-23-7 o-aminobenzaldehyde 
• 6630-33-7 ortho-bromobenzaldehyde 
• 5332-24-1 3-bromoquinoline 

Downstream Products

• 5873-00-7 3-amino-quinolin-2-ol 
• 908850-62-4 2-phenyl-furo[2,3-b]quinoline 
• 128676-85-7 2-chloro-3-iodo-quinoline 
• 841303-91-1 trifluoro-methanesulfonic acid 3-phenyl-quinolin-2-yl ester 
• 841303-92-2 4-(3-phenyl-quinolin-2-yl)-benzaldehyde 
• 38035-81-3 3-phenyl-1H-quinolin-2-one 

Relevant academic research and scientific papers

One-pot copper-catalyzed three-component reaction: A modular approach to functionalized 2-quinolones

A copper-catalyzed three-component annulation for the synthesis of functionalized 2-quinolones was developed. Three reactions including an SN2, a Knoevenagel, and finally C-N bond formation are involved in the designed cascade reaction using 2-bromoacylarenes, 2-iodoacetamide, and nucleophiles as the three components. A new catalytic system was discovered during the study and this modular approach is highly efficient to access functionalized 2-quinolone derivatives, compatible with a broad range of functional groups, scalable, and step-economic. Further derivatization of the obtained product demonstrates the synthetic utility of this method.

A concise synthesis of indoloquinoline skeletons applying two consecutive Pd-catalyzed reactions

The indoloquinoline alkaloids cryptolepine (1), neocryptolepine (2), isocryptolepine (3), and isoneocryptolepine (4) are important tools in traditional medicine. Now, their precursors 1a-4a were synthesized in two steps starting from the corresponding bromo-iodoquinolines. Our strategy is based on palladium-catalyzed reactions, applying regioselective Buchwald-Hartwig amination on 2,3- and 3,4-dihaloquinolines followed by an intramolecular Heck-type reaction. Both steps were carried out under microwave irradiation.

Synthesis of pyrido[2′,1′:2,3]imidazo[4,5-b]quinoline and pyrido[1′,2′:1,2]imidazo[4,5-b]quinoline and their benzo and aza analogs via tandem catalysis

In this paper we report regioselective tandem metal-catalyzed aminations on dihaloquinolines (2-chloro-3-iodoquinoline and 2,3-dibromoquinoline) with amino(benzo)(di)azines. Eight new heterocyclic scaffolds of the dipyridoimidazole type could be synthesized. By controlling the reaction temperature selective C-2 intermolecular Pd-catalyzed amination on 2,3-dibromoquinoline with amino(benzo)(di)azines can be achieved.

Orally active salts with tyrosine kinase activity

The present invention relates to orally active salts of compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angio-genesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.

Tyrosine kinase inhibitors

The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.