84141-89-9Relevant academic research and scientific papers
α-Adrenoreceptor Reagents. 3. Synthesis of Some 2-Substituted 1,4-Benzodioxans as Selective Presynaptic α2-Adrenoreceptor Antagonists
Stillings, Michael R.,Chapleo, Christopher B.,Butler, Richard C. M.,Davis, J. Alfred,England, C. David,et al.
, p. 1054 - 1062 (2007/10/02)
The synthesis and pharmacological activity of a series of 2-substituted derivatives of the selective α2-adrenoreceptor antagonist idazoxan (RX 781094) is described.Substitution in this position by alkyl, alkenyl, cycloalkenyl, and alkoxy groups in many cases gives compounds whose potencies and selectivities are significantly greater than those of the parent compound.
