84159-61-5Relevant academic research and scientific papers
Synthesis and herbicidal activities of aryloxyacetic acid derivatives as HPPD inhibitors
Huang, Hao,Liu, Jian-Min,Shu, Lei,Wang, Man-Man,Yan, Yi-Le,Zhang, Da-Yong,Zhang, Jian-Qiu
supporting information, p. 233 - 247 (2020/03/27)
A series of aryloxyacetic acid derivatives were designed and synthesized as 4-hydoxyphenylpyruvate dioxygenase (HPPD) inhibitors. Preliminary bioassay results reveal that these derivatives are promising Arabidopsis thaliana HPPD (AtHPPD) inhibitors, in particular compounds I12 (Ki = 0.011 μM) and I23 (Ki = 0.012 μM), which exhibit similar activities to that of mesotrione, a commercial HPPD herbicide (Ki = 0.013 μM). Furthermore, the newly synthesized compounds show significant greenhouse herbicidal activities against tested weeds at dosages of 150 g ai/ha. In particular, II4 exhibited high herbicidal activity for pre-emergence treatment that was slightly better than that of mesotrione. In addition, compound II4 was safe for weed control in maize fields at a rate of 150 g ai/ha, and was identified as the most potent candidate for a novel HPPD inhibitor herbicide. The compounds described herein may provide useful guidance for the design of new HPPD inhibiting herbicides and their modification.
The O-substitution pattern of the MoCl5-mediated oxidative aryl-aryl coupling reaction
Kramer, Beate,Fr?hlich, Roland,Bergander, Klaus,Waldvogel, Siegfried R.
, p. 91 - 96 (2007/10/03)
Different protective groups for the phenolic oxygen were investigated in the molybdenum pentachloride-mediated dehydrodimerization reaction. Cyclic acetals and ketals, triisopropylsilyl and alkoxycarbonylmethyl moieties are compatible with the strong acidic reaction conditions.
