84162-82-3

Basic information

• Product Name: 1-Acetyl-4-(2,4-difluorobenzoyl)piperidine
• Synonyms: 1-Acetyl-4-(2,4-difluorobenzoyl)piperidine;1-[4-(2,4-difluorobenzoyl)-1-piperidinyl]-1-ethanone;Risperidone Impurity 19
• CAS NO: 84162-82-3
• Molecular Formula: C₁₄H₁₅F₂NO₂
• Molecular Weight: 267.2712064
• Mol File: 84162-82-3.mol
• Article Data: 12

Chemical Properties

• Melting Point: 97-98℃
• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Acetyl-4-(2,4-difluorobenzoyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Acetyl-4-(2,4-difluorobenzoyl)piperidine(84162-82-3)
• EPA Substance Registry System: 1-Acetyl-4-(2,4-difluorobenzoyl)piperidine(84162-82-3)

Safety Data

• Hazardous Substances Data: 84162-82-3(Hazardous Substances Data)

Upstream product

• 372-18-9 1,3-Difluorobenzene 
• 59084-16-1 1-acetylpiperidine-4-carbonyl chloride 
• 25503-90-6 1-acetyl-piperidine-4-carboxylic acid 

Downstream Products

• 142369-23-1 1-acetyl-4-(6-fluoro-2-methylbenzofuran-4-yl)piperidine 
• 140213-18-9 1-[4-(2-Ethyl-6-fluoro-benzofuran-3-yl)-piperidin-1-yl]-ethanone 
• 140213-26-9 1-{4-[6-Fluoro-2-(4-fluoro-phenyl)-benzofuran-3-yl]-piperidin-1-yl}-ethanone 
• 131416-05-2 1-Acetyl-4-[2,4-di[(4-benzyl)piperidino]benzoyl]piperidine 
• 131416-04-1 1-Acetyl-4-[2,4-di(piperidino)benzoyl]piperidine 
• 84163-13-3 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride 
• 98295-40-0 1-acetyl-4-(2,4-difluorobenzoyl)piperidine hydrazone 
• 135634-18-3 (2,4-difluorophenyl)-piperidin-4-yl-methanone oxime hydrochloride 
• 131416-59-6 1-Acetyl-4-[2,4-bis(dimethylamino)]benzoylpiperidine 
• 133365-63-6 1-acetyl-4-(2-fluoro-4-morpholinobenzoyl)-piperidine 
• 133365-64-7 1-acetyl-4-(4-fluoro-2-morpholinobenzoyl)-piperidine 
• 140213-21-4 1-acetyl-4-(6-fluoro-2-phenylbenzofuran-4-yl)piperidine 

Relevant articles and documents

Purification method of 6-fluoro-3-(4-piperidyl)-1,2-benzoisoxazole hydrochloride

The invention discloses a purification method of a risperidone intermediate 6-fluoro-3-(4-piperidyl)-1,2-benzoisoxazole hydrochloride as shown in a formula II, which is characterized by comprising the following steps: adding 6-fluoro-3-(4-piperidyl)-1,2-benzoisoxazole hydrochloride into ethanol, adding a certain amount of water, and carrying out heating reflux until the solution is clear to obtain the risperidone intermediate 6-fluoro-3-(4-piperidyl)-1,2-benzoisoxazole hydrochloride; and cooling the compound to a certain temperature for crystal growing, then cooling the mixture to -5 to 10 DEG C, and filtering and drying the mixture to obtain the crystal. According to the purification method of the 6-fluoro-3-(4-piperidyl)-1,2-benzoisoxazole hydrochloride, the dimer shown as the formula V can be effectively separated out, the purification yield is 85% or above, the chemical purity of a finished product can reach 99.9% or above, an amplification effect cannot be generated in large-scale production, and the process is stable.

Aralkylpiperidine (or piperazinecarboxylic) and its derivatives used for treating hypercalcemia schinzopherenia

PROBLEM TO BE SOLVED: To provide an agent for treating schizophrenia and related neuropsychiatric diseases.SOLUTION: This invention provides an aralkylpiperidine (or piperazine) derivative represented by formula (1), where A ring is a 5-7 membered heterocycle including N, with the heterocycle including a hetero atom arbitrarily selected from O, S, N; X is O, an amino group or a substituted amino group; Z is CH, N or C; Y is O, N or S; n is an integer of 1-5; and R1-R6 are H, a C1-C4 alkyl group or the like.

ARALKYL SUBSTITUTED PIPERIDINE OR PIPERAZINE DERIVATIVES AND THEIR USE FOR TREATING SCHIZOPHRENIA

The present invention discloses an aralkyl substituted piperidine or piperazine derivative and the use of the derivative in preparation of medicaments for treating schizophrenia and correlative psychoneuroses. It is shown by pharmacological tests that the derivative of the present invention has better antischizophrenic effect and less toxicity. Said derivative is a free base or salt of the compound having the following general formula.