135634-18-3

Basic information

• Product Name: 2,4-Difluorophenyl-(4-piperidinyl)methanone oxime hydrochloride
• Synonyms: (2,4-Difluorophenyl)(piperidin-4-yl)methanone oxime hydrochloride;(2, 4-dp)-piperidin-4-yl-methanone oximehcl;2,4-DIFLUOROPHENYL-(4-PIPERIDINYL)METHANONE OXIME HYDROCHLORIDE;(2,4-Difluorophenyl)-4-piperidylMethanone OxiMe Hydrochloride
• CAS NO: 135634-18-3
• Molecular Formula: C₁₂H₁₄F₂N₂O*ClH
• Molecular Weight: 276.71
• EINECS: 1308068-626-2
• Mol File: 135634-18-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 383.2°C at 760 mmHg
• Flash Point: 185.6°C
• Appearance: /
• Vapor Pressure: 1.48E-06mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2,4-Difluorophenyl-(4-piperidinyl)methanone oxime hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Difluorophenyl-(4-piperidinyl)methanone oxime hydrochloride(135634-18-3)
• EPA Substance Registry System: 2,4-Difluorophenyl-(4-piperidinyl)methanone oxime hydrochloride(135634-18-3)

Safety Data

• Hazardous Substances Data: 135634-18-3(Hazardous Substances Data)

Usage

Uses

NH26248 is used in preparation of Iloperidone. Also, used in preparation of Amine derivatives as Potassium channel blockers useful in treatment and prevention of autoimmune and inflammatory diseases.

InChI:InChI=1/C12H14F2N2O.ClH/c13-9-1-2-10(11(14)7-9)12(16-17)8-3-5-15-6-4-8;/h1-2,7-8,15,17H,3-6H2;1H/b16-12+;

Upstream product

• 498-94-2 isonipecotic acid 
• 75-34-3 1,1-dichloroethane 
• 372-18-9 1,3-Difluorobenzene 
• 100-36-7 N,N-diethylethylenediamine 
• 84162-82-3 1-[4-(2.4-Difluoro-benzoyl)-piperidin-1-yl]-ethanone 
• 59084-16-1 1-acetylpiperidine-4-carbonyl chloride 

Downstream Products

• 84163-77-9 6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole 
• 84163-13-3 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride 
• 1141761-80-9 3-(2-{4-((2,4-difluorophenyl)hydroxyiminomethyl)piperidin-1-yl}ethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-pyrido[1,2-a]pyrimidin-4-one 
• 158697-66-6 C₂₃H₂₈F₂N₄O₂ 
• 106266-06-2 Risperidone 
• 1414778-23-6 1-(2,4-difluorophenyl)-1-(1-methylpiperidin-4-yl)methanamine 

Relevant articles and documents

Preparation method of iloperidone intermediate

The invention relates to a preparation method of an iloperidone intermediate. The preparation method comprises the following steps of (1) adding potassium hydroxide into methyl alcohol, and adding (2,4-difluorophenyl)-(4-piperidyl)ketoxime hydrochloride; (2) heating, and reacting for 2 to 3h at the controlled temperature of 50 to 60 DEG C; (3) cooling to room temperature, adding anhydrous MgSO4, stirring for 0.8 to 1.2h, sucking and filtering, and performing vacuum concentration on filtrate; (4) adding acetone, stirring for 0.4 to 0.6h at the room temperature, filtering, dripping a saturated HCl methyl alcohol solution while stirring the filtrate, so as to adjust a pH (potential of hydrogen) value to 2-3, sucking and filtering, and drying, so as to obtain a white solid, wherein the water content of methyl alcohol is less than 0.5%.

ARALKYL SUBSTITUTED PIPERIDINE OR PIPERAZINE DERIVATIVES AND THEIR USE FOR TREATING SCHIZOPHRENIA

The present invention discloses an aralkyl substituted piperidine or piperazine derivative and the use of the derivative in preparation of medicaments for treating schizophrenia and correlative psychoneuroses. It is shown by pharmacological tests that the derivative of the present invention has better antischizophrenic effect and less toxicity. Said derivative is a free base or salt of the compound having the following general formula.