84163-52-0 Usage
Uses
Used in Pharmaceutical Industry:
(E)-1-Acetyl-N-(acetyloxy)-α-(5-fluoro-2-hydroxyphenyl)-4-piperidinemethanimine is used as a key intermediate in the synthesis of Risperidone (R525000), an atypical antipsychotic drug. It plays a crucial role in the production process, enabling the formation of the final drug product with desired therapeutic properties. (E)-1-Acetyl-N-(acetyloxy)-α-(5-fluoro-2-hydroxyphenyl)-4-piperidinemethanimine's unique structure allows for the development of Risperidone, which is effective in treating various psychiatric disorders, including schizophrenia, bipolar disorder, and irritability associated with autistic disorder.
Additionally, as a precursor in the synthesis of Risperidone, (E)-1-Acetyl-N-(acetyloxy)-α-(5-fluoro-2-hydroxyphenyl)-4-piperidinemethanimine may also be used in the preparation of Risperidone impurities. These impurities are essential for quality control purposes, ensuring the safety, efficacy, and purity of the final drug product. By understanding and controlling the presence of these impurities, pharmaceutical manufacturers can maintain high standards of drug quality and comply with regulatory requirements.
Check Digit Verification of cas no
The CAS Registry Mumber 84163-52-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,4,1,6 and 3 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 84163-52:
(7*8)+(6*4)+(5*1)+(4*6)+(3*3)+(2*5)+(1*2)=130
130 % 10 = 0
So 84163-52-0 is a valid CAS Registry Number.
84163-52-0Relevant academic research and scientific papers
Synthesis and Neuroleptic Activity of 3-(1-Substituted-4-piperidinyl)-1,2-benzisoxazoles
Strupczewski, Joseph T.,Allen, Richard C.,Gardner, Beth Ann,Schmid, Blaine L.,Stache, Ulrich,et al.
, p. 761 - 769 (2007/10/02)
The synthesis of a series of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles is described.The neuroleptic activity of the series was evaluated by utilizing the climbing mice assay and inhibition of spiroperidol binding.Structure-activity relationships were studied by variation of the substituent on the benzisoxazole ring with concomitant variation of four different 1-piperidinyl substituents.Maximum neuroleptic activity was realized when there was a 6-fluoro substituent on the benzisoxazole ring.The 1-piperidinyl substituent appeared less significant, although in most cases, the (1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)propyl group imparted maximum potency.The most potent compound in both assays was 6-fluoro-3--4-piperidinyl>-1,2-benzisoxazole (11b).
