84163-64-4

Usage

Uses

Used in Scientific Research:
5-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole is used as a research chemical for the development of pharmacologically active compounds due to its unique molecular structure and properties.
Used in Neuropharmacology:
In the field of neuropharmacology, 5-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole is used as a key component in the study of compounds that interact with the nervous system, potentially leading to the discovery of new treatments for neurological disorders.
Used in Drug Development:
5-Fluoro-3-(4-Piperidinyl)-1,2-Benzisoxazole is utilized as a building block in the synthesis of new drugs, particularly those targeting the central nervous system, due to its potential to modulate neurotransmission and other neurobiological processes.

InChI:InChI=1/C12H13FN2O/c13-9-1-2-11-10(7-9)12(15-16-11)8-3-5-14-6-4-8/h1-2,7-8,14H,3-6H2

Upstream product

• 691007-07-5 (2,4-Difluoro-phenyl)-piperidin-4-yl-methanone oxime 
• 84163-46-2 (2,4-difluorophenyl)(4-piperidinyl)methanone oxime 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 735294-25-4 5-fluorobenzisoxazole 
• 691007-05-3 C₁₂H₁₄F₂N₂O 

Downstream Products

• 106266-06-2 Risperidone 
• 84163-16-6 4-(5-fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride 

Relevant academic research and scientific papers

Oxidative degradation of paliperidone using potassium permangnate in acid medium

Oxidative degradation reactions of paliperidone are studied using potassium permanganate in acidic medium spectrophotometrically. Complete reaction was carried out in pseudo first order condition. The reaction orders were calculated with respect to the paliperidone and acid, the obtained values indicate that these reactant have less than first order dependency on the reaction rate. Oxidation products were identified using LC-MS technique and their m/z values were found to be 207, 221 and 443. Kinetics and the mechanism of the reactions were derived from the results identified. The reactions were studied at four different temperatures with different paliperidone and acid concentrations. The activation and thermodynamic parameters were calculated by graphical method.

4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: Part 2. Pyridazine-based analogs

Design, synthesis, and biological evaluation of pyridazine-based, 4-bicyclic heteroaryl-piperidine derivatives as potent stearoyl-CoA desaturase-1 (SCD1) inhibitors are described. In a chronic study of selected analog (3e) in Zucker fa/fa (ZF) rat, dose-dependent decrease of body weight gain and plasma fatty acid desaturation index (DI) in both C16 and C18 are also demonstrated. The results indicate that the plasma fatty acid DI may serve as an indicator for direct target engagement and biomarker for SCD1 inhibition.

Process for making risperidone and intermediates therefor

The formation of risperidone is enhanced by the use of enriched Z-isomer oxime intermediate(s) of formula (3) or (7). The oxime(s) can be isomerically enriched by a variety of techniques including the use of the novel acetic acid salt thereof, which affords, inter alia, resolution of the isomers and/or by heat conversion.

Inhibitors of serotonin reuptake

This invention provides compounds and a method for the inhibition of serotonin reuptake in mammals.