84163-46-2

Basic information

• Product Name: 2,4-Difluorophenyl-(4-piperidinyl)methanoneoxime
• Synonyms: 2,4-Difluorophenyl-(4-piperidinyl)methanoneoxime
• CAS NO: 84163-46-2
• Molecular Weight: 240.253
• Mol File: 84163-46-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,4-Difluorophenyl-(4-piperidinyl)methanoneoxime(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Difluorophenyl-(4-piperidinyl)methanoneoxime(84163-46-2)
• EPA Substance Registry System: 2,4-Difluorophenyl-(4-piperidinyl)methanoneoxime(84163-46-2)

Safety Data

• Hazardous Substances Data: 84163-46-2(Hazardous Substances Data)

Usage

General Description

2,4-Difluorophenyl-(4-piperidinyl)methanoneoxime is a chemical compound that belongs to the oxime class of organic compounds. It is characterized by a structure consisting of a difluorophenyl group and a piperidinylmethanoneoxime moiety. 2,4-Difluorophenyl-(4-piperidinyl)methanoneoxime has potential applications in medicinal chemistry, particularly in the development of pharmaceuticals and drug discovery. Its unique structure and properties make it a valuable tool in the study of biological processes and the development of new therapeutic agents. However, further research and testing are needed to fully understand its pharmacological potential and any potential risks associated with its use.

Upstream product

• 84162-82-3 1-[4-(2.4-Difluoro-benzoyl)-piperidin-1-yl]-ethanone 
• 59084-16-1 1-acetylpiperidine-4-carbonyl chloride 
• 372-18-9 1,3-Difluorobenzene 
• 84162-86-7 (2,4-difluorophenyl)(4-piperidinyl)methanone 

Downstream Products

• 84163-13-3 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride 
• 84163-77-9 6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole 
• 133454-47-4 iloperidone 
• 1141761-79-6 C₃₀H₃₀F₂N₄O₃ 
• 158697-66-6 C₂₃H₂₈F₂N₄O₂ 
• 84163-64-4 5-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole 
• 106266-06-2 Risperidone 
• 864971-59-5 C-(2,4-difluorophenyl)-C-piperidin-4-yl-methylamine 

Relevant articles and documents

Purification method of 6-fluoro-3-(4-piperidyl)-1,2-benzoisoxazole hydrochloride

The invention discloses a purification method of a risperidone intermediate 6-fluoro-3-(4-piperidyl)-1,2-benzoisoxazole hydrochloride as shown in a formula II, which is characterized by comprising the following steps: adding 6-fluoro-3-(4-piperidyl)-1,2-benzoisoxazole hydrochloride into ethanol, adding a certain amount of water, and carrying out heating reflux until the solution is clear to obtain the risperidone intermediate 6-fluoro-3-(4-piperidyl)-1,2-benzoisoxazole hydrochloride; and cooling the compound to a certain temperature for crystal growing, then cooling the mixture to -5 to 10 DEG C, and filtering and drying the mixture to obtain the crystal. According to the purification method of the 6-fluoro-3-(4-piperidyl)-1,2-benzoisoxazole hydrochloride, the dimer shown as the formula V can be effectively separated out, the purification yield is 85% or above, the chemical purity of a finished product can reach 99.9% or above, an amplification effect cannot be generated in large-scale production, and the process is stable.

Process for making risperidone and intermediates therefor

The formation of risperidone is enhanced by the use of enriched Z-isomer oxime intermediate(s) of formula (3) or (7). The oxime(s) can be isomerically enriched by a variety of techniques including the use of the novel acetic acid salt thereof, which affords, inter alia, resolution of the isomers and/or by heat conversion.