84163-46-2

Usage

Uses

Used in Pharmaceutical Development:
2,4-Difluorophenyl-(4-piperidinyl)methanoneoxime is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a potential candidate for the development of new drugs with novel mechanisms of action.
Used in Drug Discovery:
In the field of drug discovery, 2,4-Difluorophenyl-(4-piperidinyl)methanoneoxime is used as a starting material or a building block for the design and synthesis of new bioactive compounds. Its structural features can be exploited to create molecules with specific biological activities, potentially leading to the discovery of new therapeutic agents.
Used in Medicinal Chemistry Research:
2,4-Difluorophenyl-(4-piperidinyl)methanoneoxime is used as a research tool in medicinal chemistry to study the structure-activity relationships of various biologically active compounds. Its unique structural features can provide insights into the design of more effective and selective drugs.
However, it is important to note that further research and testing are needed to fully understand the pharmacological potential of 2,4-Difluorophenyl-(4-piperidinyl)methanoneoxime and any potential risks associated with its use.

Upstream product

• 84162-86-7 (2,4-difluorophenyl)(4-piperidinyl)methanone 
• 372-18-9 1,3-Difluorobenzene 
• 59084-16-1 1-acetylpiperidine-4-carbonyl chloride 
• 84162-82-3 1-[4-(2.4-Difluoro-benzoyl)-piperidin-1-yl]-ethanone 

Downstream Products

• 84163-13-3 6-fluoro-3-(piperidin-4-yl)benzo[d]isoxazole hydrochloride 
• 84163-77-9 6-fluoro-3-(4-piperidinyl)benzo[d]isoxazole 
• 133454-47-4 iloperidone 
• 1141761-79-6 C₃₀H₃₀F₂N₄O₃ 
• 158697-66-6 C₂₃H₂₈F₂N₄O₂ 
• 84163-64-4 5-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole 
• 106266-06-2 Risperidone 
• 864971-59-5 C-(2,4-difluorophenyl)-C-piperidin-4-yl-methylamine 

Relevant academic research and scientific papers

Purification method of 6-fluoro-3-(4-piperidyl)-1,2-benzoisoxazole hydrochloride

The invention discloses a purification method of a risperidone intermediate 6-fluoro-3-(4-piperidyl)-1,2-benzoisoxazole hydrochloride as shown in a formula II, which is characterized by comprising the following steps: adding 6-fluoro-3-(4-piperidyl)-1,2-benzoisoxazole hydrochloride into ethanol, adding a certain amount of water, and carrying out heating reflux until the solution is clear to obtain the risperidone intermediate 6-fluoro-3-(4-piperidyl)-1,2-benzoisoxazole hydrochloride; and cooling the compound to a certain temperature for crystal growing, then cooling the mixture to -5 to 10 DEG C, and filtering and drying the mixture to obtain the crystal. According to the purification method of the 6-fluoro-3-(4-piperidyl)-1,2-benzoisoxazole hydrochloride, the dimer shown as the formula V can be effectively separated out, the purification yield is 85% or above, the chemical purity of a finished product can reach 99.9% or above, an amplification effect cannot be generated in large-scale production, and the process is stable.

Preparation method of risperidone

The invention discloses a preparation method of risperidone, and belongs to the technical field of preparation methods for chemical medical intermediates. High-purity risperidone is prepared by performing oximation, cyclization and condensation reactions on 2,4- difluorophenyl-4,-piperidone methanone hydrochloride and 3-(2-chloroethyl)-6,7,8,9-tetrahydro-2-methyl-4H-pyridino-[1,2-a]pyridine-4-ketone as raw materials. The method disclosed by the invention has the advantages of adoption of relatively cheap and readily-available raw materials, easiness in operation, higher yield and higher industrial value.

Process for making risperidone and intermediates therefor

The formation of risperidone is enhanced by the use of enriched Z-isomer oxime intermediate(s) of formula (3) or (7). The oxime(s) can be isomerically enriched by a variety of techniques including the use of the novel acetic acid salt thereof, which affords, inter alia, resolution of the isomers and/or by heat conversion.