84184-53-2Relevant academic research and scientific papers
Palladium-Catalyzed Formylation of Alkenylzinc Reagents with S-(4-Nitrophenyl) Thioformate
Haraguchi, Ryosuke,Tanazawa, Sho-Go,Tokunaga, Naoya,Fukuzawa, Shin-Ichi
supporting information, p. 1761 - 1764 (2018/04/27)
We report the synthesis of enal compounds by palladium-catalyzed formylation of alkenylzinc reagents with S-(4-nitrophenyl) thioformate. Various functional groups were tolerated in the present reaction. 1H NMR experiments revealed that the products had a non-protected formyl group, which can be utilized for further C–C bond formation reactions. We successfully achieved the one-pot synthesis of a 1,5-diene-3-ol compound via sequential formylation and allylation.
Linear diarylheptanoids as potential anticancer therapeutics: synthesis, biological evaluation, and structure–activity relationship studies
Motiur Rahman,Lu, Yang,Lee, Hwa-Jong,Jo, Hyunji,Yin, Wencui,Alam, Mohammad Sayed,Cha, Hyochang,Kadi, Adnan A.,Kwon, Youngjoo,Jahng, Yurngdong
, p. 1 - 18 (2018/04/16)
In efforts to develop effective anticancer therapeutics with greater selectivity toward cancerous cell and reduced side-effects, such as emetic effects due to detrimental action of the drug toward the intestinal flora, a series of linear diarylheptanoids (LDHs) were designed and synthesized in 7 steps with good-to-moderate yields. All synthesized compounds were evaluated for their antibacterial, antiproliferative, and topoisomerase-I and -IIα inhibitory activity. Overall, all compounds showed little to no activity against the bacterial strains tested. Most of the synthesized compounds showed good antiproliferative activity against human breast cancer cell lines (T47D); specifically, the IC50 values of compounds 6a, 6d, 7j, and 7e were 0.09, 0.64, 0.67, and 0.99 μM, respectively. Among the tested compounds, 7b inhibited topo-I by 9.3% (camptothecin 68.8%), 7e and 7h inhibited topo-IIα by 38.4 and 47.4% (etoposide 76.9%), respectively, at the concentration of 100 μM. These results suggest that a set of promising anticancer agents can be obtained by reducing inhibitory actions on different microbes to provide enhanced selectivity against cancerous cells.
Iron(III) chloride-promoted isomerization of propargyl alcohols to α,β-unsaturated carbonyl compounds
El Douhaibi, Ahmad Samih,Judeh, Zaher M. A.,Basri, Hedaya,Moussa, Ziad,Messali, Mouslim,Qi, Gao
experimental part, p. 533 - 540 (2011/04/22)
Aryl propargyl alcohols bearing a terminal alkynyl moiety can undergo a facile iron(III) chloride-promoted transformation to the corresponding α,β-unsaturated aldehyde in good yield and excellent stereoselectivity.
Chemoenzymatic total synthesis of the phytotoxic lactone herbarumin III
Nanda, Samik
, p. 3661 - 3663 (2007/10/03)
Asymmetric total synthesis of phytotoxic nonenolide herbarumin III was accomplished by a chemoenzymatic approach. The main highlight of the synthesis was to fix the hydroxyl stereocenters (C7 and C9) by lipase catalyzed irreversible transesterification.
Studies on the Chemical Constituents of Rutaceous Plants. Part 45. Novel Phenyl Propanoids: Cuspidiol, Boninenal, and Methyl Boninenalate
Ishii, Hisashi,Ishikawa, Tsutomu,Tohojoh, Toshiaki,Murakami, Keiko,Kawanable, Eri,et al.
, p. 2051 - 2058 (2007/10/02)
Cuspidiol, boninenal, and methyl boninenalate were established as having the structures 3-phenyl>propanol (1), (E)-3-phenyl>propenal (2), and (E)-3-phenyl>propenal (3) respectively.The three compounds were also independently synthesized.
5,6-Benzoisoindolines
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, (2008/06/13)
4-Phenyl-9,9a-dihydro-5,6-benzoisoindolines, e.g. those of the formula STR1 OR SALTS THEREOF ARE ANTIASTHMATIC AND ANTIALLERGIC AGENTS.
