84186-28-7

Upstream product

• 110-89-4 piperidine 
• 602-01-7 1-methyl-2,3-dinitrobenzene 
• 111-24-0 1,5-dibromo-pentane 
• 570-24-1 2-Methyl-6-nitroaniline 
• 3970-40-9 2-chloro-3-nitrotoluene 

Downstream Products

• 84186-30-1 3-methyl-2-piperidin-1-yl-phenylamine 
• 84186-32-3 9-methyl-1,2,3,4-tetrahydropyrido<1,2-a>benzimidazole 

Relevant academic research and scientific papers

C-fms kinase inhibitors

The invention is directed to compounds of Formulae I: wherein A, R1, R2, R3, R4, X, and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.

Theoretical Calculations of Chemical Interactions. Part 4. Aromatic Nucleophilic Substitutions and SN2 Reactions of 4- and 6-Substituted 2-Nitroanisoles

The reactions of 4-R- and 6-R-2-nitroanisoles (R=Me, Br) in neat cyclohexylamine and piperidine have been studied.The reactions with cyclohexylamine lead to the respective aromatic nucleophilic substitution products while the reactions with piperidine mainly yield the substituted nitrophenols.It was found that 6-R-2-nitroanisoles react faster than the respective 4-R-2-nitroanisoles.The absence of the expected primary steric effect is thought to be due to the spatial arrangement of the methoxide group, which adopts a conformation perpendicular to the ring plane when it is surrounded by two ortho-substituents.CNDO and INDO calculations for different conformations of the substrates give support to this assumption.

SUBSTITUTION OF NITRO GROUPS IN 2,3-DINITROTOLUENE

The reaction of 2,3-dinitrotoluene with piperidine gives a mixture of 2-piperidino-3-nitrotoluene and 3-piperidino-2-nitrotoluene in a ratio of 3:7.