84199-02-0Relevant academic research and scientific papers
Chiral ureas and thioureas supported on polystyrene for enantioselective aza-Henry reactions under solvent-free conditions
Pedrosa, Rafael,Andrés, José M.,ávila, Deisy P.,Ceballos, Miriam,Pindado, Rodrigo
, p. 2217 - 2225 (2015)
Novel bifunctional ureas and thioureas immobilized on sulfonylpolystyrene have been prepared as recoverable and reusable organocatalysts and have been used in the stereoselective aza-Henry reaction under solvent-free conditions. The activity and stereoselection of the catalysts are dependent on the length of the tether bridging the active site and the polymer, the catalyst derived from 1,6-hexane diamine being the best one. It has also been demonstrated that the supported catalysts are more effective than the homologous soluble catalysts.
