84211-44-9

Upstream product

• 490-11-9 3,4-pyridinecarboxylic acid 
• 84211-44-9 cis-2,4-piperidinedicarboxylic acid 
• 205646-60-2 dimethyl 6-cyanopyridine-3,4-dicarboxylate 
• 1796-83-4 dimethyl 3,4-pyridinedicarboxylate 
• 490-28-8 pyridine-2,4,5-tricarboxylic acid 
• 99627-66-4 cis-2,4-piperidinedicarboxylic acid hydrochloride 
• 89663-05-8 3,4-bis(methoxycarbonyl)pyridin-1-ium-1-olate 

Downstream Products

• 94769-27-4 (2S,4R)-1-(3-Acetylsulfanyl-propionyl)-piperidine-2,4-dicarboxylic acid 
• 84211-44-9 trans-2,4-piperidinedicarboxylic acid 

Relevant academic research and scientific papers

Synthesis of (2S*,4R*,5S*)-piperidinetricarboxylic acid, a non-proteinogenic amino acid isolated from clitocybe acromelalga

(255*,4R*,5S*)-Piperidinetricarboxylic acid isolated from a poisonous mushroom Clitocybe acromelalga was synthesized along with its stereoisomers and their depolarizing activity was tested.

SYNTHESIS AND CONFIGURATION OF DIASTEREOMERIC 2,4-, 2,5-, AND 2,6-PIPERIDINEDICARBOXYLIC ACIDS AND THEIR DIMETHYL ESTERS

The reduction in an acidic medium over a platinum catalysts of 2,4-, 2,5-, and 2,6-pyridinedicarboxylic acids gave cis-2,4-, -2,5-, and -2,6-piperidinedicarboxylic acids, heating of which in an alkaline medium led to thermodynamically equilibrium mixtures of diastereomers.Individual trans-2,5-piperidinecarboxylic acid was isolated.The configurations of the 2,4-, 2,5-, and 2,6-piperidinedicarboxylic acids and their methyl esters were established by means of the PMR spectra.