842130-48-7

Basic information

• Product Name: Ethyl2-(chloromethyl)thiazole-4-carboxylate
• Synonyms: Ethyl2-(chloromethyl)thiazole-4-carboxylate;2-(Chloromethyl)-1,3-thiazole-4-carboxylic acid ethyl ester;Ethyl 2-(chloromethyl)-1,3-thiazole-4-carboxylate;2-(Chloromethyl)-4-(ethoxycarbonyl)-1,3-thiazole;4-Thiazolecarboxylic acid, 2-(chloromethyl)-, ethyl ester
• CAS NO: 842130-48-7
• Molecular Formula: C₇H₈ClNO₂S
• Molecular Weight: 205.664
• Mol File: 842130-48-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 277℃
• Flash Point: 121℃
• Appearance: /
• Density: 1.333
• CAS DataBase Reference: Ethyl2-(chloromethyl)thiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl2-(chloromethyl)thiazole-4-carboxylate(842130-48-7)
• EPA Substance Registry System: Ethyl2-(chloromethyl)thiazole-4-carboxylate(842130-48-7)

Safety Data

• Hazardous Substances Data: 842130-48-7(Hazardous Substances Data)

Usage

General Description

Ethyl2-(chloromethyl)thiazole-4-carboxylate is a chemical compound with the molecular formula C9H10ClNO2S and a molecular weight of 215.7 g/mol. It is a thiazole derivative containing both an ethyl ester and a chloromethyl group. Ethyl2-(chloromethyl)thiazole-4-carboxylate is used in pharmaceutical research and development, as it has shown potential as a building block in the synthesis of bioactive compounds. It has also been studied for its potential biological activities, including antimicrobial and antifungal properties. Research on its uses and potential applications continues, as scientists work to understand its properties and potential as a drug candidate or precursor.

Upstream product

• 3018-12-0 dichloroacetonitrile 
• 868-59-7 L-cysteine ethyl ester hydrochloride 
• 40235-65-2 ethyl 2-(hydroxymethyl)-thiazole-4-carboxylate 
• 73956-17-9 ethyl 2-formyl-1,3-thiazole-4-carboxylate 
• 6436-59-5 ethyl 2-methylthiazole-4-carboxylate 
• 70-23-5 ethyl Bromopyruvate 

Downstream Products

• 91711-96-5 2-Aminomethyl₄-thiazolcarbonsaeure-ethylester 
• 82586-66-1 ethyl 2-(dimethylaminomethyl)-4-thiazolecarboxylate 

Relevant articles and documents

Solid-Phase Synthesis of Azole-Comprising Peptidomimetics and Coordination of a Designed Analog to Zn2+

Peptidomimetics that can coordinate transition metals have a variety of potential applications as catalysts, sensors, or materials. A new modular peptidomimetic scaffold, the “azole peptoid”, is introduced here. We report methods for the solid-phase synthesis of eleven examples of trimeric N-substituted oligoamides that include oxazole- or thiazole-functionalized backbones. The products prepared comprise a diversity of functionality, including a metal-coordinating terpyridine group. The modular synthetic approach enables ready preparation of analogs for specific applications. To highlight a potential use of this new synthetic scaffold, a trimeric azole peptoid functionalized with a terpyridine residue was prepared and studied. The characteristic 2:1 ligand:metal binding of this terpyridine-functionalized azole peptoid to Zn2+ in aqueous solution was observed. These studies introduce azole peptoids as a useful class of biomimetic molecules for further study and application.