842167-66-2

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 842167-64-0 2-[(benzyloxy)methyl]-1-bromo-4-fluorobenzene 
• 100-51-6 benzyl alcohol 
• 112399-50-5 2-bromo-5-fluorobenzyl bromide 
• 202865-66-5 2-bromo-5-fluorobenzyl alcohol 
• 94569-84-3 2-bromo-5-fluorobenzaldehyde 
• 100-39-0 benzyl bromide 

Downstream Products

• 842167-47-9 2-[(benzyloxy)methyl]-4-fluoro-1-vinylbenzene 

Relevant academic research and scientific papers

Divergent Access to Seven/Five-Membered Rings Based on [1,6]-Hydride Shift/Cyclization Process

We have achieved a divergent access to seven/five-membered rings based on a [1,6]-hydride shift/cyclization process from benzylidenemalonate with an o-alkoxymethyl group. Whereas Yb(OTf)3 afforded benzoxepines (with a seven-membered ring) selectively, indanes (with a five-membered ring) were the main products when Sc(OTf)3 was employed.

Copper-catalyzed allylations of zirconocene intermediates generated from o-alkenyl or o-alkynylbenzyl ether derivatives and zirconocene-butene complex

(Chemical Equation Presented) o-Alkenyl or alkynyl benzylzirconocene intermediate, which was readily generated by the reaction of 2-alkoxymethyl-styrene or 2-alkoxymethyl-1-(trimethylsilylethynyl)-benzene derivative with zirconocene-butene complex (Negishi reagent, "Cp 2Zr"), reacted with allyl or propargyl halides in the presence of a catalytic amount of CuCl to give allylation or allenylation products. Conversion to Dane's diene, which is a key intermediate for estrone synthesis, was efficiently carried out by enyne olefin metathesis of the allylation products.